Derivation of two induced pluripotent stem cell lines from a healthy control subject
Stem cell research, Vol.82, 103621
2025
: 39642595
Two human induced pluripotent stem cell lines, LEIi021-A and LEIi021-B, were derived from dermal fibroblasts from a healthy control subject from an Australian Aboriginal family with retinitis pigmentosa-11. Reprogramming was performed using episomal vectors expressing OCT4, SOX2, LIN28, L-MYC, KLF4 and mp53DD. Pluripotency markers were expressed in both LEIi021-A and LEIi021-B lines. The two cell lines displayed normal karyotypes and demonstrated the ability to differentiate into embryoid bodies with the three primary germ layers and retinal pigment epithelial cells.
- Derivation of two induced pluripotent stem cell lines from a healthy control subject
- Dan Zhang - Lions Eye InstituteDi Huang - Lions Eye InstituteLeon M Larcher - Lions Eye InstituteKhine Zaw - Lions Eye InstituteShang-Chih Chen - Lions Eye InstituteLuke Jennings - Lions Eye InstituteTina M Lamey - Sir Charles Gairdner HospitalJennifer A Thompson - Sir Charles Gairdner HospitalTerri L McLaren - Sir Charles Gairdner HospitalFred K Chen - Lions Eye InstituteSamuel McLenachan - Lions Eye Institute
- Stem cell research, Vol.82, 103621
- Elsevier Inc
- 991005884843107891
- © 2024 The Authors.
- Personalised Medicine Centre
- English
- Journal article
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