Journal article
Dermatomyositis, polymyositis and immune-mediated necrotising myopathies
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol.1852(4), pp.622-632
2015
Abstract
Dermatomyositis, polymyositis and immune-mediated necrotising myopathy are major forms of idiopathic inflammatory myopathy. We review here recent developments in understanding the pathology and pathogenesis of these diseases, and characterisation of autoantibody biomarkers. Dermatomyositis is traditionally considered to be due to a complement-mediated microangiopathy but the factors responsible for complement activation remain uncertain. Recent studies have emphasised the importance of the type I interferon pathway in the pathogenesis of the disease and have identified autoantibodies with specificities for different clinical subgroups of patients. Polymyositis is characterised by a cytotoxic T cell response targeting as yet unidentified muscle antigens presented by MHC Class I molecules, and can occur in isolation but is more often part of a multi-systemic overlap syndrome. The immune-mediated necrotising myopathies are heterogeneous and are distinguished from polymyositis by the sparseness of inflammatory infiltrates and recognition of an association with specific autoantibodies such as anti-SRP and anti-HMGCR in many cases.
Details
- Title
- Dermatomyositis, polymyositis and immune-mediated necrotising myopathies
- Authors/Creators
- Y-B Luo (Author/Creator) - The University of Western AustraliaF.L. Mastaglia (Author/Creator) - Murdoch University
- Publication Details
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol.1852(4), pp.622-632
- Publisher
- Elsevier BV
- Identifiers
- 991005546329707891
- Copyright
- © 2014 Elsevier B.V.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology
- ESI research areas
- Clinical Medicine