Design, development and deployment of a web-based patient registry for rare genetic lipid disorders

K.R. Napier; A.J. Hooper; D.M. Ng; L. Render; D.A. Bell; J. Pang; G.F. Watts; M.I. Bellgard; J.R. Burnett

doi:10.1016/j.pathol.2020.02.002

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Design, development and deployment of a web-based patient registry for rare genetic lipid disorders

Journal article

Peer reviewed

Design, development and deployment of a web-based patient registry for rare genetic lipid disorders

K.R. Napier, A.J. Hooper, D.M. Ng, L. Render, D.A. Bell, J. Pang, G.F. Watts, M.I. Bellgard and J.R. Burnett

Pathology, Vol.52(4), pp.447-452

2020

DOI: https://doi.org/10.1016/j.pathol.2020.02.002

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Abstract

Rare genetic lipid disorders comprise all the monogenic disorders of lipoprotein metabolism with the exception of heterozygous familial hypercholesterolaemia (FH). The creation and maintenance of patient registries is critical for disease monitoring, improving clinical best practice, facilitating research and enabling the development of novel therapeutics, but very few disease-specific rare genetic lipid disorder registries currently exist. Our aim was to design, develop and deploy a web-based patient registry for rare genetic lipid disorders. The Rare Genetic Lipid Disorders Registry is based on the FH Australasia Network (FHAN) Registry, which has been operating since 2015. The Rare Genetic Lipid Disorders Registry was deployed utilising the open-source Rare Disease Registry Framework (RDRF), which enables the efficient customisation and sustainable deployment of web-based registries. The Registry has been designed to capture longitudinal data on 13 rare genetic lipid disorders, with the ability to add more if required in the future. Recruitment of volunteers into the Registry is currently through the Royal Perth Hospital Lipid Disorders Clinic in Western Australia. Although in essence a clinic-based patient registry, the web-based design allows for expansion and distribution across Australia and beyond. Data collated by the Registry may ultimately improve the diagnosis, management and treatment of these conditions.

Details

Title: Design, development and deployment of a web-based patient registry for rare genetic lipid disorders
Authors/Creators: K.R. Napier (Author/Creator) - Murdoch University
A.J. Hooper (Author/Creator) - The University of Western Australia
D.M. Ng (Author/Creator) - The University of Western Australia
L. Render (Author/Creator) - Murdoch University
D.A. Bell (Author/Creator) - The University of Western Australia
J. Pang (Author/Creator) - The University of Western Australia
G.F. Watts (Author/Creator) - Royal Perth Hospital
M.I. Bellgard (Author/Creator) - Queensland University of Technology
J.R. Burnett (Author/Creator) - Royal Perth Hospital
Publication Details: Pathology, Vol.52(4), pp.447-452
Publisher: Elsevier BV
Identifiers: 991005543327707891
Copyright: © 2020 Royal College of Pathologists of Australasia.
Murdoch Affiliation: Centre for Comparative Genomics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.155 Medical Ethics; 1.155.1510 Orphan Drugs
Web Of Science research areas: Pathology
ESI research areas: Clinical Medicine