Journal article
Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials
Chemical Communications, Vol.54(82), pp.11538-11541
2018
Abstract
We report a novel multifunctional hyperbranched polymer based on polyethylene glycol (PEG) as a nanomedicine platform that facilitates longitudinal and quantitative 89Zr-PET imaging, enhancing knowledge of nanomaterial biodistribution and pharmacokinetics/pharmacodynamics both in vivo and ex vivo. Anti-VEGF-A DNA aptamer functionalization increased tumour accumulation by >2-fold in a breast cancer model.
Details
- Title
- Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials
- Authors/Creators
- N.L. Fletcher (Author/Creator)Z.H. Houston (Author/Creator)J.D. Simpson (Author/Creator)R.N. Veedu (Author/Creator)K.J. Thurecht (Author/Creator)
- Publication Details
- Chemical Communications, Vol.54(82), pp.11538-11541
- Publisher
- Royal Society of Chemistry
- Identifiers
- 991005544386807891
- Copyright
- ©The Royal Society of Chemistry 2018
- Murdoch Affiliation
- Centre for Comparative Genomics
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
34 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 2 Chemistry
- 2.53 Polymers & Macromolecules
- 2.53.70 Nanocarrier Drug Delivery
- Web Of Science research areas
- Chemistry, Multidisciplinary
- ESI research areas
- Chemistry