Journal article
Detection of avian H7N9 influenza A viruses in the Yangtze Delta Region of China during early H7N9 outbreaks
Avian Diseases, Vol.60(1s), pp.118-125
2016
PMCID: PMC4911810
PMID: 27309047
Abstract
Since the first H7N9 human case in Shanghai, February 19, 2013, the emerging avian-origin H7N9 influenza A virus has become an epizootic virus in China, posing a potential pandemic threat to public health. From April 2 to April 28, 2013, some 422 oral-pharyngeal and cloacal swabs were collected from birds and environmental surfaces at five live poultry markets (LPMs) and 13 backyard poultry farms (BPFs) across three cities, Wuxi, Suzhou, and Nanjing, in the Yangtze Delta region. In total 22 isolates were recovered, and six were subtyped as H7N9, nine as H9N2, four as H7N9/H9N2, and three unsubtyped influenza A viruses. Genomic sequences showed that the HA and NA genes of the H7N9 viruses were similar to those of the H7N9 human isolates, as well as other avian-origin H7N9 isolates in the region, but the PB1, PA, NP, and MP genes of the sequenced viruses were more diverse. Among the four H7N9/H9N2 mixed infections, three were from LPM, whereas the other one was from the ducks at one BPF, which were H7N9 negative in serologic analyses. A survey of the bird trading records of the LPMs and BPFs indicates that trading was a likely route for virus transmission across these regions. Our results suggested that better biosecurity and more effective vaccination should be implemented in backyard farms, in addition to biosecurity management in LPMs.
Details
- Title
- Detection of avian H7N9 influenza A viruses in the Yangtze Delta Region of China during early H7N9 outbreaks
- Authors/Creators
- Yin Li - These authors contributed equally to this workXin-Mei Huang - These authors contributed equally to this workDong-Min Zhao - These authors contributed equally to this workYu-Zhuo Liu - Jiangsu Academy of Agricultural SciencesKong-Wang He - Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou, Jiangsu Province, ChinaYao-Xing Liu - Jiangsu Animal Disease Control Center, Nanjing, Jiangsu Province, ChinaChang-Hai Chen - Jiangsu Animal Disease Control Center, Nanjing, Jiangsu Province, ChinaLi-Ping Long - Mississippi State UniversityYifei Xu - Mississippi State UniversityXing-Xing Xie - Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou, Jiangsu Province, ChinaKai-Kai Han - Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou, Jiangsu Province, ChinaXiao-Yan Liu - Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou, Jiangsu Province, ChinaJing Yang - Jiangsu Academy of Agricultural SciencesYou-Fa Zhang - Animal Husbandry and Veterinary Medicine Station of Suzhou, Suzhou, Jiangsu Province, ChinaFeng Fan - China Animal Disease Control CenterRichard Webby - St. Jude Children's Research HospitalXiu-Feng Wan - Mississippi State University
- Publication Details
- Avian Diseases, Vol.60(1s), pp.118-125
- Publisher
- The American Association of Avian Pathologists
- Number of pages
- 8
- Identifiers
- 991005578639607891
- Copyright
- © 2016 American Association of Avian Pathologists
- Murdoch Affiliation
- Centre for Biosecurity and One Health
- Language
- English
- Resource Type
- Journal article
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- 1.104 Virology - General
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