Journal article
Detection of filovirus-reactive antibodies in Australian bat species
Journal of General Virology, Vol.103(8), Art. 001785
2022
Abstract
Bats have been implicated as the reservoir hosts of filoviruses in Africa, with serological evidence of filoviruses in various bat species identified in other countries. Here, serum samples from 190 bats, comprising 12 different species, collected in Australia were evaluated for filovirus antibodies. An in-house indirect microsphere assay to detect antibodies that cross-react with Ebola virus (Zaire ebolavirus; EBOV) nucleoprotein (NP) followed by an immunofluorescence assay (IFA) were used to confirm immunoreactivity to EBOV and Reston virus (Reston ebolavirus; RESTV). We found 27 of 102 Yinpterochiroptera and 19 of 88 Yangochiroptera samples were positive to EBOV NP in the microsphere assay. Further testing of these NP positive samples by IFA revealed nine bat sera that showed binding to ebolavirus-infected cells. This is the first report of filovirus-reactive antibodies detected in Australian bat species and suggests that novel filoviruses may be circulating in Australian bats.
Details
- Title
- Detection of filovirus-reactive antibodies in Australian bat species
- Authors/Creators
- J. Barr (Author/Creator) - Australian Centre for Disease PreparednessV. Boyd (Author/Creator) - Australian Centre for Disease PreparednessS. Todd (Author/Creator) - Australian Centre for Disease PreparednessI. Smith (Author/Creator) - CSIRO Health and BiosecurityD. Prada (Author/Creator) - Murdoch UniversityM. O'Dea (Author/Creator) - Murdoch UniversityB. Jackson (Author/Creator) - Murdoch UniversityL. Pearce (Author/Creator) - CSIRO ManufacturingT.E. Adams (Author/Creator) - CSIRO ManufacturingE. Vanderduys (Author/Creator) - CSIRO Land and WaterD. Westcott (Author/Creator) - CSIRO Land and WaterA. McKeown (Author/Creator) - CSIRO Land and WaterM.L. Baker (Author/Creator) - Australian Centre for Disease PreparednessG.A. Marsh (Author/Creator) - Australian Centre for Disease Preparedness
- Publication Details
- Journal of General Virology, Vol.103(8), Art. 001785
- Publisher
- Society for General Microbiology
- Identifiers
- 991005542351007891
- Copyright
- © 2022 The Authors.
- Murdoch Affiliation
- School of Veterinary Medicine; Harry Butler Institute
- Language
- English
- Resource Type
- Journal article
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