Journal article
Determinants of 6-month survival of critically ill patients with an active hematologic malignancy
Journal of Critical Care, Vol.36, pp.252-258
2016
Abstract
Purpose This study assessed the determinants of 6-month survival of critically ill patients with an active hematologic malignancy (HM). Methods All patients with an active HM defined by either receiving ongoing or due to receive antineoplastic therapy, admitted to 2 tertiary intensive care units between 2010 and 2015, were included in this retrospective cohort study. Results Of the 273 patients included in the study (median age, 63 [interquartile range, 54-71] years; 40.7% female), 116 (42.5%; 95% confidence interval, 36.8-48.4) died in hospital. The 6-month mortality was 56.4% (95% confidence interval, 50.5-62.2). Mechanical ventilation, intensive care unit admission source, and the type of active HM were significantly associated with hospital mortality and 6-month survival, after adjusting for severity of acute illness. The type of active HM was the most important prognostic factor, with over a 10-fold difference in 6-month survival between HM with the best and worst prognosis. In addition, recent hematopoietic stem cell transplant (<30 days) was associated with a better 6-month survival. Conclusion Differences in 6-month survival between critically ill patients with different types of active HM were substantial. Recent hematopoietic stem cell transplant, severity of illness, and use of mechanical ventilation were additional important determinants of 6-month survival in patients with an active HM.
Details
- Title
- Determinants of 6-month survival of critically ill patients with an active hematologic malignancy
- Authors/Creators
- S. Richards (Author/Creator)B. Wibrow (Author/Creator)M. Anstey (Author/Creator)H. Sidiqi (Author/Creator)A. Chee (Author/Creator)K.M. Ho (Author/Creator)
- Publication Details
- Journal of Critical Care, Vol.36, pp.252-258
- Publisher
- Elsevier B.V.
- Identifiers
- 991005541645107891
- Copyright
- © 2016 Elsevier Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.154 Assisted Ventilation
- 1.154.1088 Intensive Care
- Web Of Science research areas
- Critical Care Medicine
- ESI research areas
- Clinical Medicine