Determination of normal values using an automated coagulation timer for activated coagulation time and its application in dogs with hemophilia

Bemhard Gerber; Joseph Taboada; Clinton D. Lothrop Jr; Andre Busato; Giselle Hosgood; Susan A. Goodman; Frédéric P. Gaschen

doi:10.1111/j.1939-1676.1999.tb01459.x

Back

Determination of normal values using an automated coagulation timer for activated coagulation time and its application in dogs with hemophilia

Journal article

Open access

Peer reviewed

Determination of normal values using an automated coagulation timer for activated coagulation time and its application in dogs with hemophilia

Bemhard Gerber, Joseph Taboada, Clinton D. Lothrop Jr, Andre Busato, Giselle Hosgood, Susan A. Goodman and Frédéric P. Gaschen

Journal of veterinary internal medicine, Vol.13(5), pp.433-436

Revised February 16, 1999; Accepted February 19, 1999

1999

DOI: https://doi.org/10.1111/j.1939-1676.1999.tb01459.x

PMID: 10499726

Files and links (1)

url

PublishedView

Published (Version of Record) Open

Abstract

Activated partial thromboplastin time

Bleeding disorder

Diatomite

Kaolin

Medtronic HemoTec ACT analyzer

Vacutainer

The present study was performed to determine normal values for the Medtronic HemoTec automated activated coagulation time (ACT) analyzer (Medtronic HemoTec Inc, Parker, CO, distributed in Switzerland by Convergenza AG, Vaduz, Liechtenstein), and to evaluate its ability to detect dogs with hemophilia. ACT was measured in 43 healthy dogs presented to the Companion Animal Hospital, University of Bern, Bern, Switzerland, with the Medtronic HemoTec ACT analyzer to determine normal values. The mean ± 2 standard deviations (SDs) of the values obtained was defined as the normal range. ACT was measured 8–10 times on the same day in 6 dogs to determine repeatability. ACT also was measured in 11 dogs with hemophilia and compared with a conventional visual ACT measurement test and with the activated partial thromboplastin time (APTT). ACT values of the 43 dogs used to determine normal values ranged from 66.5 to 97.0 seconds (mean, 79.3 seconds; SD, 7.35 seconds; median, 78.5 seconds). A range of 64–95 seconds (mean ± 2 SDs) was defined as the normal range for the tested device. Repeatability was poor (r= 0.256). ACT values measured with the automated device did not correlate with ACT values measured with a conventional visual test or with APTT. Sensitivity of the test was 90.9%, specificity was 98.0%, and accuracy was 96.7%. Variability in the test results was large and may lead to incorrect results. The automated measurement device was not superior to the conventional visual method in evaluating dogs with hemophilia.

Details

Title: Determination of normal values using an automated coagulation timer for activated coagulation time and its application in dogs with hemophilia
Authors/Creators: Bemhard Gerber - University of Bern
Joseph Taboada - Louisiana State University
Clinton D. Lothrop Jr - Auburn University
Andre Busato - University of Bern
Giselle Hosgood - Louisiana State University
Susan A. Goodman - University of Bern
Frédéric P. Gaschen - University of Bern
Publication Details: Journal of veterinary internal medicine, Vol.13(5), pp.433-436
Publisher: Blackwell Publishing Ltd
Edition: Revised February 16, 1999; Accepted February 19, 1999
Number of pages: 4
Identifiers: 991005592764107891
Murdoch Affiliation: School of Veterinary Medicine
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

20 Record Views

10 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.75 Blood Clotting; 1.75.324 Transfusion
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science