Journal article
Development of Cell-Specific aptamers: Recent advances and insight into the selection procedures
Molecules, Vol.22(12)
2017
Abstract
Systematic evolution of ligands by exponential enrichment (SELEX) is an established procedure for developing short single-stranded nucleic acid ligands called aptamers against a target of choice. This approach has also been used for developing aptamers specific to whole cells named Cell-SELEX. Aptamers selected by Cell-SELEX have the potential to act as cell specific therapeutics, cell specific markers or cell specific drug delivery and imaging agents. However, aptamer development is a laborious and time-consuming process which is often challenging due to the requirement of frequent optimization of various steps involved in Cell-SELEX procedures. This review provides an insight into various procedures for selection, aptamer enrichment, regeneration and aptamer-binding analysis, in addition to a very recent update on all aptamers selected by Cell-SELEX procedures.
Details
- Title
- Development of Cell-Specific aptamers: Recent advances and insight into the selection procedures
- Authors/Creators
- K. Rahimizadeh (Author/Creator)H. Al Shamaileh (Author/Creator)M. Fratini (Author/Creator)M. Chakravarthy (Author/Creator)M. Stephen (Author/Creator)S. Shigdar (Author/Creator)R. Veedu (Author/Creator)
- Publication Details
- Molecules, Vol.22(12)
- Publisher
- MDPI
- Identifiers
- 991005545267007891
- Copyright
- © 2017 MDPI AG
- Murdoch Affiliation
- Centre for Comparative Genomics
- Language
- English
- Resource Type
- Journal article
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