Development of an In Vivo Extended-Spectrum Cephalosporin-Resistant Escherichia coli Model in Post-Weaned Pigs and its use in assessment of Dietary Interventions

Tanya Laird; David Jordan; John Pluske; Josie Mansfield; Stuart Wilkinson; David Cadogan; Sam Abraham; Mark O'Dea

doi:10.3390/ani13060959

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Development of an In Vivo Extended-Spectrum Cephalosporin-Resistant Escherichia coli Model in Post-Weaned Pigs and its use in assessment of Dietary Interventions

Journal article

Open access

Peer reviewed

Development of an In Vivo Extended-Spectrum Cephalosporin-Resistant Escherichia coli Model in Post-Weaned Pigs and its use in assessment of Dietary Interventions

Tanya Laird, David Jordan, John Pluske, Josie Mansfield, Stuart Wilkinson, David Cadogan, Sam Abraham and Mark O'Dea

Animals (Basel), Vol.13(6), Art. 959

2023

DOI: https://doi.org/10.3390/ani13060959

PMID: 36978499

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Abstract

swine

antimicrobial resistance

postbiotics

Current interventions targeting antimicrobial resistance (AMR), a major impact on commercial pork production, focus on reducing the emergence of AMR by minimising antimicrobial usage through antimicrobial stewardship and a range of alternative control methods. Although these strategies require continued advancement, strategies that directly aim to reduce or eliminate existing antimicrobial resistant bacteria, specifically bacteria resistant to critically important antimicrobials (CIAs), need to be investigated and established. This study established an in vivo model for examining the effects of postbiotics, in the form of Lactobacillus acidophilus fermentation products (LFP) and Saccharomyces cerevisiae fermentation products (SFP), on the shedding of extended-spectrum cephalosporin (ESC)-resistant E. coli. The model was successful in demonstrating the presence of ESC-resistant E. coli as evidenced by its detection in 62 of 64 pigs. There was a strong trend (p = 0.065) for the SFP postbiotics to reduce the shedding of ESC-resistant E. coli, indicating positive impacts of this additive on reducing the carriage of bacteria resistant to CIAs. Overall, this in vivo model enables future evaluation of strategies targeting ESC-resistant E. coli while increasing our knowledge on the carriage of ESC-resistant E. coli in pigs.

Details

Title: Development of an In Vivo Extended-Spectrum Cephalosporin-Resistant Escherichia coli Model in Post-Weaned Pigs and its use in assessment of Dietary Interventions
Authors/Creators: Tanya Laird - Murdoch University
David Jordan - New South Wales Department of Primary Industries
John Pluske - Murdoch University
Josie Mansfield - Murdoch University
Stuart Wilkinson - Feedworks Pty Ltd., Romsey, VIC 3434, Australia
David Cadogan - Feedworks Pty Ltd., Romsey, VIC 3434, Australia
Sam Abraham - Murdoch University, Centre for Biosecurity and One Health
Mark O'Dea - Antimicrobial Resistance and Infectious Diseases Laboratory, Harry Butler Institute, Murdoch University, Murdoch, WA 6150, Australia
Publication Details: Animals (Basel), Vol.13(6), Art. 959
Grant note: A1-101 / Australasian Pork Research Institute Ltd
Identifiers: 991005566469607891
Murdoch Affiliation: Harry Butler Institute; School of Agricultural Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.146 Antimicrobial Resistance
Web Of Science research areas: Agriculture, Dairy & Animal Science; Veterinary Sciences; Zoology
ESI research areas: Plant & Animal Science