Journal article
Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease
Alzheimer's & Dementia, Vol.18(6), pp.1141-1154
2022
Abstract
Introduction
This study involved a parallel comparison of the diagnostic and longitudinal monitoring potential of plasma glial fibrillary acidic protein (GFAP), total tau (t-tau), phosphorylated tau (p-tau181 and p-tau231), and neurofilament light (NFL) in preclinical Alzheimer's disease (AD).
Methods
Plasma proteins were measured using Simoa assays in cognitively unimpaired older adults (CU), with either absence (Aβ−) or presence (Aβ+) of brain amyloidosis.
Results
Plasma GFAP, t-tau, p-tau181, and p-tau231 concentrations were higher in Aβ+ CU compared with Aβ− CU cross-sectionally. GFAP had the highest effect size and area under the curve (AUC) in differentiating between Aβ+ and Aβ− CU; however, no statistically significant differences were observed between the AUCs of GFAP, p-tau181, and p-tau231, but all were significantly higher than the AUC of NFL, and the AUC of GFAP was higher than the AUC of t-tau. The combination of a base model (BM), comprising the AD risk factors, age, sex, and apolipoprotein E gene (APOE) ε4 status with GFAP was observed to have a higher AUC (>90%) compared with the combination of BM with any of the other proteins investigated in the current study. Longitudinal analyses showed increased GFAP and p-tau181 in Aβ+ CU and increased NFL in Aβ− CU, over a 12-month duration. GFAP, p-tau181, p-tau231, and NFL showed significant correlations with cognition, whereas no significant correlations were observed with hippocampal volume.
Discussion
These findings highlight the diagnostic and longitudinal monitoring potential of GFAP and p-tau for preclinical AD.
Details
- Title
- Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease
- Authors/Creators
- P. Chatterjee (Author/Creator) - Macquarie UniversityS. Pedrini (Author/Creator) - Edith Cowan UniversityN.J. Ashton (Author/Creator) - King's College LondonM. Tegg (Author/Creator) - Edith Cowan UniversityK. Goozee (Author/Creator) - Macquarie UniversityA.K. Singh (Author/Creator) - Macquarie UniversityT.K. Karikari (Author/Creator)J. Simrén (Author/Creator) - Sahlgrenska University HospitalE. Vanmechelen (Author/Creator) - ADx NeuroSciencesN.J. Armstrong (Author/Creator) - Curtin UniversityE. Hone (Author/Creator) - Edith Cowan UniversityP.R. Asih (Author/Creator) - Flinders UniversityK. Taddei (Author/Creator) - Edith Cowan UniversityV. Doré (Author/Creator) - CSIRO Health and BiosecurityV.L. Villemagne (Author/Creator) - University of PittsburghH.R. Sohrabi (Author/Creator) - Macquarie UniversityH. Zetterberg (Author/Creator) - University of GothenburgC.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental HealthK. Blennow (Author/Creator) - Sahlgrenska University HospitalR.N. Martins (Author/Creator) - Macquarie University
- Publication Details
- Alzheimer's & Dementia, Vol.18(6), pp.1141-1154
- Publisher
- Wiley
- Identifiers
- 991005542051307891
- Copyright
- © 2021 the Alzheimer's Association
- Murdoch Affiliation
- Centre for Healthy Ageing; Health Futures Institute
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior