Journal article
Diagnostic value of subjective memory complaints assessed with a single item in dominantly inherited Alzheimer’s disease: Results of the DIAN Study
BioMed Research International, Vol.2015, Article ID 828120
2015
Abstract
Objective. We examined the diagnostic value of subjective memory complaints (SMCs) assessed with a single item in a large cross-sectional cohort consisting of families with autosomal dominant Alzheimer’s disease (ADAD) participating in the Dominantly Inherited Alzheimer Network (DIAN). Methods. The baseline sample of 183 mutation carriers (MCs) and 117 noncarriers (NCs) was divided according to Clinical Dementia Rating (CDR) scale into preclinical (CDR 0; MCs: n = 107; NCs: n = 109), early symptomatic (CDR 0.5; MCs: n = 48; NCs: n = 8), and dementia stage (CDR ≥ 1; MCs: n = 28; NCs: n = 0). These groups were subdivided by the presence or absence of SMCs. Results. At CDR 0, SMCs were present in 12.1% of MCs and 9.2% of NCs (P = 0.6). At CDR 0.5, SMCs were present in 66.7% of MCs and 62.5% of NCs (P = 1.0). At CDR ≥ 1, SMCs were present in 96.4% of MCs. SMCs in MCs were significantly associated with CDR, logical memory scores, Geriatric Depression Scale, education, and estimated years to onset.
Conclusions: The present study shows that SMCs assessed by a single-item scale have no diagnostic value to identify preclinical ADAD in asymptomatic individuals. These results demonstrate the need of further improvement of SMC measures that should be examined in large clinical trials.
Details
- Title
- Diagnostic value of subjective memory complaints assessed with a single item in dominantly inherited Alzheimer’s disease: Results of the DIAN Study
- Authors/Creators
- C. Laske (Author/Creator) - German Center for Neurodegenerative DiseasesH.R. Sohrabi (Author/Creator) - Edith Cowan UniversityM.S. Jasielec (Author/Creator) - Washington University in St. LouisS. Müller (Author/Creator) - University of TübingenN.K. Koehler (Author/Creator) - University of TübingenS. Gräber (Author/Creator) - German Center for Neurodegenerative DiseasesS. Förster (Author/Creator) - Technical University of MunichA. Drzezga (Author/Creator) - University of CologneF. Mueller-Sarnowski (Author/Creator) - Ludwig-Maximilians-Universität MünchenA. Danek (Author/Creator) - Ludwig-Maximilians-Universität MünchenM. Jucker (Author/Creator) - German Center for Neurodegenerative DiseasesR.J. Bateman (Author/Creator) - Washington University in St. LouisV. Buckles (Author/Creator) - Washington University in St. LouisA.J. Saykin (Author/Creator) - Radiology & Imaging SciencesR.N. Martins (Author/Creator) - Edith Cowan UniversityJ.C. Morris (Author/Creator) - Washington University in St. Louis
- Publication Details
- BioMed Research International, Vol.2015, Article ID 828120
- Publisher
- Hindawi Publishing Corporation
- Identifiers
- 991005541120807891
- Copyright
- © 2015 Christoph Laske et al.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
38 File views/ downloads
72 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Biotechnology & Applied Microbiology
- Medicine, Research & Experimental
- ESI research areas
- Biology & Biochemistry