Journal article
Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region
Emerging Microbes & Infections, Vol.8(1), pp.1553-1562
2019
Abstract
Molecular epidemiology of Clostridium difficile infection (CDI) has been extensively studied in North America and Europe; however, limited data on CDI are available in the Asia-Pacific region. A multicentre retrospective study was conducted in this region. C. difficile isolates were subjected to multilocus sequence typing (ST) and antimicrobial susceptibility testing. Totally, 394 isolates were collected from Hangzhou, Hong Kong, China; Busan, South Korea; Fukuoka, Japan; Singapore; Perth, Sydney, Australia; New York, the United States. C. difficile isolates included 337 toxin A-positive/B-positive/binary toxin-negative (A+B+CDT-), 48 A-B+CDT-, and nine A+B+CDT+. Distribution of dominant STs varied geographically with ST17 in Fukuoka (18.6%), Busan (56.0%), ST2 in Sydney (20.4%), Perth (25.8%). The antimicrobial resistance patterns were significantly different among the eight sites (χ2 = 325.64, p < 0.001). Five major clonal complexes correlated with unique antimicrobial resistances. Healthcare-associated (HA) CDI was mainly from older patients with more frequent antimicrobial use and higher A-B+ positive rates. Higher resistance to gatifloxacin, tetracycline, and erythromycin were observed in HA-CDI patients (χ2 = 4.76-7.89, p = 0.005-0.029). In conclusion, multiple C. difficile genotypes with varied antimicrobial resistance patterns have been circulating in the Asia-Pacific region. A-B+ isolates from older patients with prior antimicrobial use were correlated with HA-CDI.
Details
- Title
- Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region
- Authors/Creators
- Y. Luo (Author/Creator)E. Cheong (Author/Creator)Q. Bian (Author/Creator)D.A. Collins (Author/Creator)J. Ye (Author/Creator)J.H. Shin (Author/Creator)W.C. Yam (Author/Creator)T. Takata (Author/Creator)X. Song (Author/Creator)X. Wang (Author/Creator)M. Kamboj (Author/Creator)T. Gottlieb (Author/Creator)J. Jiang (Author/Creator)T.V. Riley (Author/Creator)Y-W Tang (Author/Creator)D. Jin (Author/Creator)
- Publication Details
- Emerging Microbes & Infections, Vol.8(1), pp.1553-1562
- Publisher
- Nature Publishing Group
- Identifiers
- 991005543941007891
- Copyright
- © 2019 The Author(s).
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
32 File views/ downloads
115 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.1133 Clostridium Infections
- Web Of Science research areas
- Immunology
- Infectious Diseases
- Microbiology
- ESI research areas
- Microbiology