Differential activities of alpha/beta IFN subtypes against influenza virus in vivo and enhancement of specific immune responses in DNA vaccinated mice expressing haemagglutinin and nucleoprotein

C.M. James-Berry; M.Y. Abdad; J.P. Mansfield; H.K. Jacobsen; A.R. Vind; P.A. Stumbles; E.J. Bartlett

doi:10.1016/j.vaccine.2006.10.038

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Differential activities of alpha/beta IFN subtypes against influenza virus in vivo and enhancement of specific immune responses in DNA vaccinated mice expressing haemagglutinin and nucleoprotein

Journal article

Peer reviewed

Differential activities of alpha/beta IFN subtypes against influenza virus in vivo and enhancement of specific immune responses in DNA vaccinated mice expressing haemagglutinin and nucleoprotein

C.M. James-Berry, M.Y. Abdad, J.P. Mansfield, H.K. Jacobsen, A.R. Vind, P.A. Stumbles and E.J. Bartlett

Vaccine, Vol.25(10), pp.1856-1867

2007

DOI: https://doi.org/10.1016/j.vaccine.2006.10.038

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Abstract

Vaccines are urgently needed to elicit immunity to different influenza virus strains. DNA vaccines can elicit partial protective immunity, however their efficacy requires improvement. We assessed the capacity of individual type I IFN multigene family members as subtype transgenes to abrogate influenza virus replication in a vaccination/challenge mouse model. Differences in antiviral efficacy were found among the subtypes with IFNA5 and IFNA6 being most effective, while IFNA1 was the least effective in reducing lung virus replication. Mice vaccinated with combinatorial HA/IFNA6 or NP/IFNA6 showed reduced lung viral titres, clinical score, body weight loss, and pulmonary tissue damage compared to IFNA6, HA, or NP viral vaccination alone. In addition, IFNA6 increased IgG2a titres with upregulation of IFN-gamma response in the respiratory tract. We conclude that IFN-alpha 6 has antiviral and immunomodulatory effects, which improve efficacy of DNA vaccines for enhanced control of influenza.

Details

Title: Differential activities of alpha/beta IFN subtypes against influenza virus in vivo and enhancement of specific immune responses in DNA vaccinated mice expressing haemagglutinin and nucleoprotein
Authors/Creators: C.M. James-Berry (Author/Creator)
M.Y. Abdad (Author/Creator) - Murdoch University
J.P. Mansfield (Author/Creator) - Murdoch University
H.K. Jacobsen (Author/Creator) - Murdoch University
A.R. Vind (Author/Creator) - Murdoch University
P.A. Stumbles (Author/Creator) - The Kids Research Institute Australia
E.J. Bartlett (Author/Creator) - Murdoch University
Publication Details: Vaccine, Vol.25(10), pp.1856-1867
Publisher: Elsevier BV
Identifiers: 991005543475907891
Copyright: 2006 Elsevier Ltd
Murdoch Affiliation: School of Nursing and Midwifery; School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.104 Virology - General; 1.104.126 Influenza
Web Of Science research areas: Immunology; Medicine, Research & Experimental
ESI research areas: Immunology