Differential growth inhibition of human diploid fibroblasts by 2-deoxyglucose and antimycin A with ageing in vitro

A.H. Bittles; H. Baum; N.J. Monks

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Differential growth inhibition of human diploid fibroblasts by 2-deoxyglucose and antimycin A with ageing in vitro

Journal article

Peer reviewed

Differential growth inhibition of human diploid fibroblasts by 2-deoxyglucose and antimycin A with ageing in vitro

A.H. Bittles, H. Baum and N.J. Monks

Gerontology, Vol.34(5-6), pp.236-241

1988

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Abstract

The relative growth inhibitory effects of 2-deoxyglucose and antimycin A were monitored at five stages during the life-span in vitro of human diploid fibroblasts. A marked age-dependent response was observed with 2-deoxyglucose but not with antimycin A. The results confirm an increase in the rate of glycolysis with ageing, which appears to be independent of cellular mitochondrial respiratory chain capacity. This may be associated with reduced utilization of the hexose monophosphate shunt and a consequent decline in the availability of ribose moieties for nucleic acid biosynthesis.

Details

Title: Differential growth inhibition of human diploid fibroblasts by 2-deoxyglucose and antimycin A with ageing in vitro
Authors/Creators: A.H. Bittles (Author/Creator)
H. Baum (Author/Creator)
N.J. Monks (Author/Creator)
Publication Details: Gerontology, Vol.34(5-6), pp.236-241
Publisher: Karger AG
Identifiers: 991005545559307891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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