Journal article
Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease
Frontiers in Aging Neuroscience, Vol.14, Art. 964336
2022
Abstract
Alzheimer’s disease (AD) is the most common form of dementia. Although previous studies have selectively investigated the localization of amyloid-beta (Aβ) deposition in certain brain regions, a comprehensive characterization of the rostro-caudal distribution of Aβ plaques in the brain and their inter-regional correlation remain unexplored. Our results demonstrated remarkable working and spatial memory deficits in 9-month-old 5xFAD mice compared to wildtype mice. High Aβ plaque load was detected in the somatosensory cortex, piriform cortex, thalamus, and dorsal/ventral hippocampus; moderate levels of Aβ plaques were observed in the motor cortex, orbital cortex, visual cortex, and retrosplenial dysgranular cortex; and low levels of Aβ plaques were located in the amygdala, and the cerebellum; but no Aβ plaques were found in the hypothalamus, raphe nuclei, vestibular nucleus, and cuneate nucleus. Interestingly, the deposition of Aβ plaques was positively associated with brain inter-regions including the prefrontal cortex, somatosensory cortex, medial amygdala, thalamus, and the hippocampus. In conclusion, this study provides a comprehensive morphological profile of Aβ deposition in the brain and its inter-regional correlation. This suggests an association between Aβ plaque deposition and specific brain regions in AD pathogenesis.
Details
- Title
- Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease
- Authors/Creators
- K.C. Tsui (Author/Creator) - University of Hong KongJ. Roy (Author/Creator)S.C. Chau (Author/Creator)K.H. Wong (Author/Creator)L. Shi (Author/Creator)C.H. Poon (Author/Creator)Y. Wang (Author/Creator)T. Strekalova (Author/Creator)L. Aquili (Author/Creator)R.C-C Chang (Author/Creator)M-L Fung (Author/Creator)Y-Q Song (Author/Creator)L.W. Lim (Author/Creator)
- Publication Details
- Frontiers in Aging Neuroscience, Vol.14, Art. 964336
- Publisher
- Frontiers
- Identifiers
- 991005542592407891
- Copyright
- © 2022 Tsui et al.
- Murdoch Affiliation
- School of Allied Health
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Metrics
12 File views/ downloads
90 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.57 Alzheimer's Mechanisms
- Web Of Science research areas
- Geriatrics & Gerontology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior