Distribution of sequence types and antimicrobial resistance of clinical Pseudomonas aeruginosa isolates from dogs and cats visiting a veterinary teaching hospital in Thailand

Arunee Jangsangthong; Kittitat Lugsomya; Sukanya Apiratwarrasakul; Nathita Phumthanakorn

doi:10.1186/s12917-024-04098-5

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Distribution of sequence types and antimicrobial resistance of clinical Pseudomonas aeruginosa isolates from dogs and cats visiting a veterinary teaching hospital in Thailand

Journal article

Open access

Peer reviewed

Distribution of sequence types and antimicrobial resistance of clinical Pseudomonas aeruginosa isolates from dogs and cats visiting a veterinary teaching hospital in Thailand

Arunee Jangsangthong, Kittitat Lugsomya, Sukanya Apiratwarrasakul and Nathita Phumthanakorn

BMC veterinary research, Vol.20, 234

2024

DOI: https://doi.org/10.1186/s12917-024-04098-5

PMID: 38822333

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Abstract

Animals

Anti-Bacterial Agents - pharmacology

Cat Diseases - microbiology

Cats

Dog Diseases - epidemiology

Dog Diseases - microbiology

Dogs

Drug Resistance, Bacterial

Hospitals, Animal

Hospitals, Teaching

Microbial Sensitivity Tests

Pseudomonas aeruginosa - drug effects

Pseudomonas aeruginosa - genetics

Pseudomonas aeruginosa - isolation & purification

Pseudomonas Infections - epidemiology

Pseudomonas Infections - microbiology

Pseudomonas Infections - veterinary

Thailand - epidemiology

Whole Genome Sequencing

Pseudomonas aeruginosa is an important opportunistic pathogen in dogs and cats and is resistant to several antimicrobial drugs; however, data on the clonal distribution of P. aeruginosa in veterinary hospital are limited. This study aimed to investigate the clonal dissemination and antimicrobial resistance of clinical P. aeruginosa in a veterinary teaching hospital in Thailand within a 1-year period. Minimum inhibitory concentration determination and whole genome sequencing were used for antimicrobial susceptibility analysis and genetic determination, respectively. Forty-nine P. aeruginosa were isolated mostly from the skin, urinary tract, and ear canal of 39 dogs and 10 cats. These isolates belonged to 39 sequence types (STs) that included 9 strains of high-risk clones of ST235 (n = 2), ST244 (n = 2), ST274 (n = 2), ST277 (n = 1), ST308 (n = 1), and ST357 (n = 1). Overall antimicrobial resistance rate was low (< 25%), and no colistin-resistant strains were found. Two carbapenem-resistant strains belonging to ST235 and ST3405 were identified. Clinical P. aeruginosa in dogs and cats represent STs diversity. High-risk clones and carbapenem-resistant strains are a public health concern. Nevertheless, this study was limited by a small number of isolates. Continuous monitoring is needed, particularly in large-scale settings with high numbers of P. aeruginosa, to restrict bacterial transfer from companion animal to humans in a veterinary hospital.

Details

Title: Distribution of sequence types and antimicrobial resistance of clinical Pseudomonas aeruginosa isolates from dogs and cats visiting a veterinary teaching hospital in Thailand
Authors/Creators: Arunee Jangsangthong - Mahidol University
Kittitat Lugsomya - School of Veterinary Medicine, Murdoch University, Perth, WA, Australia
Sukanya Apiratwarrasakul - Mahidol University
Nathita Phumthanakorn - Mahidol University
Publication Details: BMC veterinary research, Vol.20, 234
Publisher: BioMed Central Ltd unless otherwise stated. Part of Springer Nature
Identifiers: 991005672070007891
Murdoch Affiliation: School of Veterinary Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.146 Antimicrobial Resistance
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science