Journal article
Does APOE genotype moderate the relationship between physical activity, brain health and dementia risk? A systematic review
Ageing Research Reviews, Vol.64, Art. 101173
2020
Abstract
Introduction
For decades, researchers have tried to understand the moderating effect of APOE ε4 carriage on the relationship between physical activity (PA), brain health and dementia risk. However, this field has produced inconsistent findings.
Method
We conducted a systematic review of the literature, searching for observational and interventional studies examining the effect of APOE ε4 carriage on the relationships between PA, dementia risk and different markers of brain health.
Results
Observational studies using dementia risk as a primary outcome measure generally found that in shorter follow-up periods (up to 10 years) both APOE ε4 carriers and non-carriers benefit from PA, although longer follow-ups showed mixed results. In neuroimaging studies, mainly carriers or both groups showed benefits. Additionally, the association between PA and amyloid burden was more evident among carriers. Overall, studies with greater samples of active APOE ε4 carriers are more likely to report benefits within this group in terms of lower dementia risk and reduced brain pathology.
Discussion
Although we have identified some patterns for the modulating effect of APOE ε4 on PA and dementia or brain pathology, the available data is, overall, inconclusive. Heterogeneity in study design, methodology, and outcomes blur the ability to detect clear associations.
Details
- Title
- Does APOE genotype moderate the relationship between physical activity, brain health and dementia risk? A systematic review
- Authors/Creators
- J. de Frutos-Lucas (Author/Creator) - Universidad Autónoma de MadridN. Frost (Author/Creator) - The University of Western AustraliaK.I. Erickson (Author/Creator) - University of PittsburghJ.M. Serrano (Author/Creator) - Universidad Autónoma de MadridF. Maestú (Author/Creator) - Universidad Complutense de MadridS.M. Laws (Author/Creator) - Edith Cowan UniversityB.M. Brown (Author/Creator) - Edith Cowan University
- Publication Details
- Ageing Research Reviews, Vol.64, Art. 101173
- Publisher
- Elsevier B.V.
- Identifiers
- 991005542138907891
- Copyright
- © 2020 Elsevier B.V.
- Murdoch Affiliation
- School of Allied Health
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Cell Biology
- Geriatrics & Gerontology
- ESI research areas
- Clinical Medicine