Does inspiratory muscle training improve lung function and quality of life in people with inclusion body myositis? A pilot study

Ethan Williams; Ian Cooper; Kelly Beer; Kathryn Hird; Vinicius Cavalheri; Kathryn Watson; Merrilee Needham

doi:10.1016/j.nmd.2024.02.002

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Does inspiratory muscle training improve lung function and quality of life in people with inclusion body myositis? A pilot study

Journal article

Open access

Peer reviewed

Does inspiratory muscle training improve lung function and quality of life in people with inclusion body myositis? A pilot study

Ethan Williams, Ian Cooper, Kelly Beer, Kathryn Hird, Vinicius Cavalheri, Kathryn Watson and Merrilee Needham

Neuromuscular disorders : NMD, Vol.37, pp.6-12

2024

DOI: https://doi.org/10.1016/j.nmd.2024.02.002

PMID: 38489862

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Abstract

Diaphragm function

Exercise therapy

Inclusion body myositis

Inspiratory muscle training

Lung function

Respiratory muscle strength

Inclusion Body Myositis is the most common acquired myositis in adults, predominantly weakening forearm flexor and knee extensor muscles. Subclinical respiratory muscle weakness has recently been recognised in people with Inclusion Body Myositis, increasing their risk of respiratory complications. Inspiratory muscle training, a technique which demonstrates efficacy and safety in improving respiratory function in people with neuromuscular disorders, has never been explored in those with Inclusion Body Myositis. In this pilot study, six adults with Inclusion Body Myositis (age range 53 to 81 years) completed eight weeks of inspiratory muscle training. Measures of respiratory function, quality of life, sleep quality and a two-minute walk test were performed pre and post-intervention. All participants improved their respiratory function, with maximal inspiratory pressure, sniff nasal inspiratory pressure and forced vital capacity increasing by an average of 50 % (p = .002), 43 % (p = .018) and 13 % (p = .003) respectively. No significant change was observed in quality of life, sleep quality or two-minute walk test performance. No complications occurred due to inspiratory muscle training This pilot study provides the first evidence that inspiratory muscle training may be safe and effective in people with Inclusion Body Myositis, potentially mitigating the complications of poor respiratory function.

Details

Title: Does inspiratory muscle training improve lung function and quality of life in people with inclusion body myositis? A pilot study
Authors/Creators: Ethan Williams - School of Medicine, The University of Notre Dame, Fremantle, Western Australia, Australia
Ian Cooper - Perron Institute for Neurological and Translational Science
Kelly Beer - Perron Institute for Neurological and Translational Science
Kathryn Hird - University of Notre Dame
Vinicius Cavalheri - Curtin University
Kathryn Watson - Fiona Stanley Fremantle Hospitals Group
Merrilee Needham - University of Notre Dame
Publication Details: Neuromuscular disorders : NMD, Vol.37, pp.6-12
Publisher: Elsevier B.V
Identifiers: 991005649566207891
Murdoch Affiliation: Centre for Molecular Medicine and Innovative Therapeutics; Health Futures Institute
Language: English
Resource Type: Journal article

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