Journal article
Does memory improve with age? CD85j (ILT-2/LIR-1) expression on CD8+ T cells correlates with 'memory inflation' in human cytomegalovirus infection
Immunology and Cell Biology, Vol.83(2), pp.182-188
2005
Abstract
CMV-specific memory CD8+ T cells accumulate over time to reach high frequencies amongst peripheral blood lymphocytes – a phenomenon termed 'memory inflation'. Using tetramer staining on samples from a large number of subjects and multivariate regression analysis, we were able to relate this to the phenotype of CD8+ T cells. We made the following observations: (i) CD85j (ILT-2/LIR-1) was highly expressed alongside CD57 – an established effector memory marker – on CMV-specific CD8+ T cells; (ii) on CD8+ T cells as a whole, with increasing age, CD57 and CD85j (ILT-2/LIR-1) expression increased whereas CCR7 expression decreased, indicating increasing maturation of the total CD8+ T-cell compartment with age; (iii) unit increases in the percentage of CMV-specific CD8+ T cells expressing CD57 and CD85j (ILT-2/LIR-1) were associated with incremental expansion of these T-cell populations; (iv) CMV seropositivity is associated with a marked effect on the overall phenotype of CD8+ T cells (at any given age, CMV seropositivity is associated with an 18.7% increase in CD85j (ILT-2/LIR-1) expression); and (v) from our observations we estimated from this an apparent 'ageing effect' of CMV on CD8+ T cells of 35.4 years. The data presented are consistent with a predictable, unidirectional and linear model of virus specific T-cell differentiation and maturation.
Details
- Title
- Does memory improve with age? CD85j (ILT-2/LIR-1) expression on CD8+ T cells correlates with 'memory inflation' in human cytomegalovirus infection
- Authors/Creators
- J. Northfield (Author/Creator)M. Lucas (Author/Creator)H. Jones (Author/Creator)N.T. Young (Author/Creator)P. Klenerman (Author/Creator)
- Publication Details
- Immunology and Cell Biology, Vol.83(2), pp.182-188
- Publisher
- Nature Publishing Group
- Identifiers
- 991005542525007891
- Copyright
- © 2017 Australasian Society for Immunology
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.161 Virology - Identification & Sequencing
- 1.161.711 Cytomegalovirus Infections
- Web Of Science research areas
- Cell Biology
- Immunology
- ESI research areas
- Immunology