Journal article
Dopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC
Brain Stimulation, Vol.13(1), pp.105-108
2020
Abstract
Background
Recent evidence suggests that transcranial direct current stimulation (tDCS) may interact with the dopaminergic system to affect cognitive flexibility.
Objective/hypotheses: We examined whether putative reduction of dopamine levels through the acute phenylalanine/tyrosine depletion (APTD) procedure and excitatory anodal tDCS of the dorsolateral prefrontal cortex (dlPFC) are causally related to cognitive flexibility as measured by task switching and reversal learning.
Method
A double-blind, sham-controlled, randomised trial was conducted to test the effects of combining anodal tDCS and depletion of catecholaminergic precursor tyrosine on cognitive flexibility.
Results
Anodal tDCS and tyrosine depletion had a significant effect on task switching, but not reversal learning. Whilst perseverative errors were significantly improved by anodal tDCS, the APTD impaired reaction times. Importantly, the combination of APTD and anodal tDCS resulted in cognitive performance which did not statistically differ to that of the control condition.
Conclusions
Our results suggest that the effects of tDCS on cognitive flexibility are modulated by dopaminergic tone.
Details
- Title
- Dopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC
- Authors/Creators
- C. Borwick (Author/Creator) - Sheffield Hallam UniversityR. Lal (Author/Creator) - Sheffield Hallam UniversityL.W. Lim (Author/Creator) - University of Hong KongC.J. Stagg (Author/Creator) - Wellcome Centre for Integrative NeuroimagingL. Aquili (Author/Creator)
- Publication Details
- Brain Stimulation, Vol.13(1), pp.105-108
- Publisher
- Elsevier
- Identifiers
- 991005543365407891
- Copyright
- © 2019 Elsevier Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
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- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.811 Transcranial Magnetic Stimulation
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior