Dose-response effects of exercise on mental health in community-dwelling older adults: Exploration of genetic moderators

Swathi Gujral; Marcia Burns; Kirk I Erickson; Dana Rofey; Jeremiah J Peiffer; Simon M. Laws; Belinda Brown

doi:10.1016/j.ijchp.2024.100443

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Dose-response effects of exercise on mental health in community-dwelling older adults: Exploration of genetic moderators

Journal article

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Peer reviewed

Dose-response effects of exercise on mental health in community-dwelling older adults: Exploration of genetic moderators

Swathi Gujral, Marcia Burns, Kirk I Erickson, Dana Rofey, Jeremiah J Peiffer, Simon M. Laws and Belinda Brown

International journal of clinical and health psychology, Vol.24(1), 100443

2024

DOI: https://doi.org/10.1016/j.ijchp.2024.100443

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Abstract

Background/Objective (1) Examine the role of exercise intensity on mental health symptoms in a community-based sample of older adults. (2) Explore the moderating role of genetic variation in brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) on the effects of exercise on mental health symptoms. Method This study is a secondary analysis of a three-arm randomized controlled trial, comparing the effects of 6 months of high-intensity aerobic training vs. moderate-intensity aerobic training vs. a no-contact control group on mental health symptoms assessed using the Depression, Anxiety, and Stress Scale (DASS). The BDNF Val66Met polymorphism and APOE ε4 carrier status were explored as genetic moderators of exercise effects on mental health symptoms. Results The exercise intervention did not influence mental health symptoms. The BDNF Val66Met polymorphism did not moderate intervention effects on mental health symptoms. APOE ε4 carrier status moderated the effect of intervention group on perceived stress over 6 months, such that APOE ε4 carriers, but not non-carriers, in the high-intensity aerobic training group showed a decline in perceived stress over 6 months. Conclusions APOE ε4 carrier status may modify the benefits of high-intensity exercise on perceived stress such that APOE ε4 carriers show a greater decline in stress as a result of exercise relative to non-APOE ε4 carriers.

Details

Title: Dose-response effects of exercise on mental health in community-dwelling older adults: Exploration of genetic moderators
Authors/Creators: Swathi Gujral - University of Pittsburgh
Marcia Burns
Kirk I Erickson - University of Pittsburgh
Dana Rofey - University of Pittsburgh
Jeremiah J Peiffer - Murdoch University, Centre for Healthy Ageing
Simon M. Laws - Edith Cowan University
Belinda Brown - Murdoch University, Centre for Healthy Ageing
Publication Details: International journal of clinical and health psychology, Vol.24(1), 100443
Publisher: Elsevier B.V
Identifiers: 991005631765507891
Copyright: © 2024. The Authors
Murdoch Affiliation: Centre for Healthy Ageing
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.44 Nutrition & Dietetics; 1.44.103 Physical Activity
Web Of Science research areas: Psychology, Clinical
ESI research areas: Psychiatry/Psychology