Journal article
Dose-response studies for pituitary and testicular function in male dogs treated with the GnRH superagonist, deslorelin
Reproduction in Domestic Animals, Vol.44(5), pp.725-734
2009
Abstract
We tested the effect of dose of GnRH superagonist on pituitary and testicular function in a study with four groups of four male dogs. The Controls received blank implants and the other three groups received implants containing 3, 6 or 12 mg deslorelin (d-Trp 6-Pro 9-des-Gly 10-GnRH ethylamide). In all deslorelin-treated groups, there was initially an acute increase in plasma concentrations of LH and testosterone, followed by declines such that both hormones became undetectable after approximately 12 days. There was a dose-response in some of these early aspects of the hormone profiles. With respect to long-term effects of treatment, the 12-mg dose had significantly greater effects than the smaller doses for the duration of minimum testicular volume [366 ± 77, mean ± SEM (3 mg), 472 ± 74 (6 mg), and 634 ± 59 (12 mg) days], absence of ejaculate [416 ± 88 (3 mg), 476 ± 83 (6 mg), and 644 ± 67 (12 mg) days], undetectable plasma concentrations of LH and testosterone [367 ± 64 (3 mg), 419 ± 72 (6 mg), and 607 ± 69 (12 mg) days], the delay until complete recovery of LH and testosterone secretion [394 ± 65 (3 mg), 484 ± 72 (6 mg) and 668 ± 47 (12 mg) days], and the delay until testes had regrown to normal volume [408 ± 77 (3 mg), 514 ± 74 (6 mg), 676 ± 59 (12 mg) days]. The time taken to restore full ejaculates was also longest for the 12-mg dose: 716 ± 67 (12 mg) days vs 440 ± 66 (3 mg) and 538 ± 83 (6 mg) days after implantation. There was no correlation between delay to recovery of normal ejaculate quality and body mass. We conclude that the dose-response relationship with deslorelin implants is not expressed with respect to the degree of suppression of reproduction, but on the maximum duration of suppression and thus to delay until recovery.
Details
- Title
- Dose-response studies for pituitary and testicular function in male dogs treated with the GnRH superagonist, deslorelin
- Authors/Creators
- A. Junaidi (Author/Creator) - Murdoch UniversityP.E. Williamson (Author/Creator) - Murdoch UniversityG.B. Martin (Author/Creator) - The University of Western AustraliaM.A. Blackberry (Author/Creator) - The University of Western AustraliaJ.M. Cummins (Author/Creator) - Murdoch UniversityT.E. Trigg (Author/Creator) - Peptech Animal Health Pty Limited, Macquarie Park, NSW, Australia
- Publication Details
- Reproduction in Domestic Animals, Vol.44(5), pp.725-734
- Publisher
- Blackwell Publishing Inc.
- Identifiers
- 991005543582807891
- Copyright
- © 2008 Blackwell Verlag.
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.232 Veterinary Sciences
- 3.232.1281 Veterinary Reproductive Health
- Web Of Science research areas
- Agriculture, Dairy & Animal Science
- Reproductive Biology
- Veterinary Sciences
- ESI research areas
- Agricultural Sciences