Drug-Eluting Biodegradable Implants for the Sustained Release of Bisphosphonates

Cintya Dharmayanti; Todd A. Gillam; Desmond B. Williams; Anton Blencowe

doi:10.3390/polym12122930

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Drug-Eluting Biodegradable Implants for the Sustained Release of Bisphosphonates

Journal article

Open access

Peer reviewed

Drug-Eluting Biodegradable Implants for the Sustained Release of Bisphosphonates

Cintya Dharmayanti, Todd A. Gillam, Desmond B. Williams and Anton Blencowe

Polymers, Vol.12(12), 2930

2020

DOI: https://doi.org/10.3390/polym12122930

PMID: 33297466

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Abstract

Physical Sciences

Polymer Science

Science & Technology

Despite being one of the first-line treatments for osteoporosis, the bisphosphonate drug class exhibits an extremely low oral bioavailability (<1%) due to poor absorption from the gastrointestinal tract. To overcome this, and to explore the potential for sustained drug release, bioerodible poly(lactic acid) (PLA) and poly(D,L-lactide-co-glycolide) (PLGA) implants loaded with the bisphosphonate alendronate sodium (ALN) were prepared via hot-melt extrusion. The rate of drug release in vitro was modulated by tailoring the ratio of lactide to glycolide in the polymer and by altering the ALN-loading of the implants. All investigated implants exhibited sustained ALN release in vitro between 25 to 130 days, where implants of greater glycolide composition and higher ALN-loadings released ALN more rapidly. All PLGA implants demonstrated a sigmoidal release profile, characterised by an initial surface dissolution phase, followed by a period of zero-order drug diffusion, then relaxation or erosion of the polymer chains that caused accelerated release over the subsequent days. Contrastingly, the PLA implants demonstrated a logarithmic release profile, characterised by a gradual decrease in ALN release over time.

Details

Title: Drug-Eluting Biodegradable Implants for the Sustained Release of Bisphosphonates
Authors/Creators: Cintya Dharmayanti - University of South Australia
Todd A. Gillam - University of South Australia
Desmond B. Williams - University of South Australia
Anton Blencowe - University of South Australia
Publication Details: Polymers, Vol.12(12), 2930
Publisher: MDPI
Number of pages: 14
Grant note: Playford Trust (South Australia) Scheer Family
Identifiers: 991005845393607891
Murdoch Affiliation: School of Mathematics, Statistics, Chemistry and Physics
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.80 Bone Diseases; 1.80.1211 Bisphosphonates
Web Of Science research areas: Polymer Science
ESI research areas: Chemistry