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Journal article
Drug hypersensitivity reactions in children in clinical practice: A WAO Statement
The World Allergy Organization journal, Vol.18(9), 101087
01/09/2025
PMID: 40933958
Abstract
Drug hypersensitivity reactions (DHRs) in children and adolescents are less common than in adults but can have serious consequences if mismanaged. Mislabeling children as drug-allergic due to incomplete diagnostic evaluations leads to unnecessary medication restrictions, increased healthcare costs, and suboptimal treatment choices. This Statement from the World Allergy Organization (WAO) provides evidence-based recommendations for evaluating and managing pediatric DHRs, emphasizing accurate diagnosis through in vivo and in vitro testing, risk stratification, and personalized approaches. Antibiotics, particularly β-lactams, and non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently implicated drugs, with non-immediate reactions, such as maculopapular exanthema, being the most common presentation. The document also addresses emerging concerns, including monoclonal antibody-induced anaphylaxis and drug-induced enterocolitis syndrome. It underscores the need for specialized care in allergy centers with expertise in pediatric populations and advocates for multidisciplinary programs to manage complex cases, such as chemotherapy hypersensitivity and perioperative drug allergy. By addressing diagnostic challenges and clinical uncertainties, this document aims to improve the management of DHRs in children, reduce mislabeling, and enhance patient outcomes worldwide.
Details
- Title
- Drug hypersensitivity reactions in children in clinical practice: A WAO Statement
- Authors/Creators
- M. Pilar Berges-Gimeno - Hospital Universitario Ramón y CajalEmilio Alvarez-Cuesta - ENT and AllergyMarina Atanaskovic-Markovic - University of BelgradeMarina Attanassi - University of Chieti-PescaraCarlo Caffareli - MedicinaJean Christoph Caubet - Pediatric Allergy Unit, Department of Woman, Child and Adolescent, Geneva University Hospitals, Geneva, SwitzerlandGeorge du Toit - Guy's and St Thomas' NHS Foundation TrustAntonieta Guzman-Melendez - Hospital Clínico de la Universidad de ChileSemanur Kuyucu - Mersin ÜniversitesiRicardo Madrigal-Burgaleta - St Bartholomew's HospitalLina Mayorga - Hospital Regional Universitario de MálagaElizabeth Powell - Guy's and St Thomas' NHS Foundation TrustMichelle Ramien - University of CalgaryEva Rebelo Gomes - Hospital de Santo AntónioFrancesca Mori - Meyer Children's HospitalAndrew A. White - Scripps ClinicIgnacio J. Ansotegui - Hospital Quirónsalud BarcelonaMarcelo Vivolo Aun - Universidade de São PauloAnnick Barbaud - InsermLorena Bernal-Rubio - Hospital Universitario Ramón y CajalSevim Bavbek - Ankara UniversityKnut Brockow - Technical University of MunichLucrecia Bustamante - Hospital Italiano de Buenos AiresYoon Seok Chang - Seoul National University Bundang HospitalLuis Felipe Chiaverini Ensina - Universidade de São PauloJavier Cuesta-Herranz - Hospital Universitario Fundación Jiménez DíazBryan N. Fernandes - St Bartholomew's HospitalLene Heise Garvey - University of CopenhagenPedro Giavina-Bianchi - Universidade de São PauloMona I. Kidon - Sheba Medical CenterMarina Labella Alvarez - Hospital Regional Universitario de MálagaJoanna S. Makowska - University of ŁódźSusana Marinho - Manchester University NHS Foundation TrustDavid Alejandro Mendoza-Hernández - Instituto Nacional de PediatriaMauro Pagani - ItalyValeria Palma Pino - Hospital Clínico de la Universidad de ChileClaudio A.S. Parisi - Hospital Italiano de Buenos AiresHae Sim Park - Ajou UniversityJonathan Peter - University of Cape TownElizabeth J. Phillips - Vanderbilt University Medical CenterKimberly Risma - Cincinnati Children's Hospital Medical CenterEmilio Solano-Solares - Instituto CajalLuciana Kase Tanno - Centre Hospitalier Universitaire de MontpellierRocco Luigi Valluzzi - Bambino Gesù Children's HospitalPaula Vazquez-Revuelta - Institut Català d'OrnitologiaTimothy J. Watts - Homerton University Hospital NHS Foundation TrustMasao Yamaguchi - Teikyo University Chiba Medical CenterReview Panel Authors
- Publication Details
- The World Allergy Organization journal, Vol.18(9), 101087
- Publisher
- Elsevier Inc
- Identifiers
- 991005884938907891
- Copyright
- © 2025 The Author(s).
- Murdoch Affiliation
- Research and Innovation Office; Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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