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Journal article
Dual-Site Beta tACS Over the rIFG and preSMA-Induced Phase-Specific Changes in Functional Connectivity but not Response Inhibition Performance in Older Adults
Psychophysiology, Vol.62(5), e70060
2025
PMID: 40323015
Abstract
Research suggests that changes in functional connectivity contribute to age-related declines in response inhibition. Through a double-blind crossover study, we investigated the effects of dual-site beta transcranial alternating current stimulation (tACS) over the right inferior frontal gyrus (rIFG) and pre-supplementary motor area (preSMA) on functional connectivity measured with electroencephalography and response inhibition (stop-signal task performance) in 15 older (aged 61-79 years) and 18 young (aged 18-34 years) adults. Two tACS conditions were administered in separate sessions: in-phase tACS, where electrical currents delivered to rIFG and preSMA had a 0° phase difference, and anti-phase tACS, where currents had a 180° phase difference. Resting-state beta band rIFG-preSMA connectivity significantly increased after in-phase tACS for older and young adults and decreased after anti-phase tACS for older adults. Response inhibition significantly improved after both in- and anti-phase tACS for young and older adults. These findings suggest that tACS can potentially modulate rIFG-preSMA connectivity in a phase-specific manner in the aging brain, and that inhibitory performance might not be directly regulated by resting-state rIFG-preSMA phase connectivity. Due to the lack of sham control, placebo effects cannot be ruled out. However, the differing neurophysiological effects from in- and anti-phase tACS suggest that rIFG-preSMA resting-state phase connectivity is unlikely to underpin the changes in inhibitory performance. Future studies incorporating a sham control are required to verify these findings.
Details
- Title
- Dual-Site Beta tACS Over the rIFG and preSMA-Induced Phase-Specific Changes in Functional Connectivity but not Response Inhibition Performance in Older Adults
- Authors/Creators
- Jane Tan - Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Perth, Western Australia, AustraliaKartik K Iyer - QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaMichael A Nitsche - Leibniz Research Centre for Working Environment and Human FactorsRohan Puri - University of TasmaniaMark R Hinder - University of TasmaniaHakuei Fujiyama - Murdoch University, Centre for Healthy Ageing
- Publication Details
- Psychophysiology, Vol.62(5), e70060
- Publisher
- Wiley Periodicals LLC on behalf of Society for Psychophysiological Research.
- Number of pages
- 13
- Grant note
- 57384703 / Australia-Germany Joint Research Co-operation (DAAD) DP200101696 / Australian Research Council 711-1641 / Dementia Australia Research Foundation FT150100406 / Australian Research Council
- Identifiers
- 991005778129607891
- Copyright
- © 2025 The Author(s).
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.811 Transcranial Magnetic Stimulation
- Web Of Science research areas
- Neurosciences
- Physiology
- Psychology
- Psychology, Biological
- Psychology, Experimental
- ESI research areas
- Psychiatry/Psychology