Journal article
Duplication and Polymorphism in the MHC: Alu Generated Diversity and Polymorphism Within the PERB11 Gene Family
Hereditas, Vol.127(1-2), pp.37-46
Accepted July 20, 1997
1997
PMID: 9420468
Abstract
The PERB11 gene family has at least five members within the telomeric region of the MHC. The PERB11.1 and PERB11.2 genes are approximately 40 kb and 160 kb centromeric of HLA-B, respectively. Using continuous genomic sequence encompassing PERB11.1 and PERB11.2, we have found a large (approximately 25 kb) segmental duplication extending beyond the genes themselves and other potential coding sequences. The major difference between the segments are large indels which are predominantly Alu sequences. The Alu sequences within the duplicated segments have created diversity via the internal and 3′ poly A-rich region. A sequence comparison of an Alu sequence between two different human ancestral haplotypes shows a high level of polymorphism, particularly in the poly A-rich regions. This study characterises the Alu sequences within the peri-PERB11.1 and peri-PERBI 11.2 duplicated segments in relation to diversity and polymorphism and as evolutionary markers.
Details
- Title
- Duplication and Polymorphism in the MHC: Alu Generated Diversity and Polymorphism Within the PERB11 Gene Family
- Authors/Creators
- Silvana Gaudieri - The University of Western AustraliaKeith M. Giles - The University of Western AustraliaJerzy K. Kulski - The University of Western AustraliaRoger L. Dawkins - The University of Western Australia
- Publication Details
- Hereditas, Vol.127(1-2), pp.37-46
- Publisher
- Munksgaard International Publishers
- Edition
- Accepted July 20, 1997
- Number of pages
- 10
- Identifiers
- 991005624466107891
- Copyright
- © 1997 John Wiley & Sons
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.607 MHC Diversity
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics