Journal article
Duration of action of mepivacaine and lidocaine in equine palmar digital perineural blocks in an experimental lameness model
Veterinary Surgery, Vol.46(7), pp.986-993
2017
Abstract
Objective: To establish and compare the onset and duration of action of 2 local anesthetics based on objective lameness and skin sensitivity assessment. Study design: Interventional crossover experimental trial with balanced randomization. Animals: Eight horses. Methods: Reversible forelimb lameness was induced in 8 horses. A palmar digital nerve block (PDNB) was applied with mepivacaine or lidocaine (both 2%). Quantitative lameness and skin sensitivity data were collected with an inertial sensor system and a force gauge, respectively. The times to lameness resolution/skin desensitization (T1), consistent lameness detection/partial return of skin sensitivity (T2), and complete return of lameness/skin sensitivity (T3) were determined and compared between treatments and assessment methods. Results: Mepivacaine blocks resolved lameness in 8/8 horses, compared to 3/8 horses with lidocaine blocks. Both agents led to skin desensitization in 8/8 horses. Skin desensitization occurred sooner than lameness resolution after mepivacaine (P =.047). Duration of action was longer with mepivacaine than lidocaine (mean T3_lameness mepivacaine 366 minutes, lidocaine 113 minutes (P =.038); T3_skin mepivacaine 195 minutes, lidocaine 63 minutes [P ≤.001]). Skin sensitivity returned sooner than lameness after lidocaine block at T3 (P =.015). Conclusion: The use of lidocaine in PDNBs for the purpose of lameness diagnosis should be reassessed, as it may not resolve lameness despite loss of skin sensation. Mepivacaine is superior, with a reliable onset and longer duration of action. Skin desensitization as an indicator for the onset of action or effectiveness of PDNBs for mepivacaine and lidocaine, or as a measure of the duration of action of lidocaine PDNBs should be interpreted with caution.
Details
- Title
- Duration of action of mepivacaine and lidocaine in equine palmar digital perineural blocks in an experimental lameness model
- Authors/Creators
- M. Hoerdemann (Author/Creator) - Murdoch UniversityR.L. Smith (Author/Creator) - Murdoch UniversityG. Hosgood (Author/Creator) - Murdoch University
- Publication Details
- Veterinary Surgery, Vol.46(7), pp.986-993
- Publisher
- W. B. Saunders Co., Ltd.
- Identifiers
- 991005540040407891
- Copyright
- © 2017 The American College of Veterinary Surgeons
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- 3.232 Veterinary Sciences
- 3.232.1304 Equine Orthopedics
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- Plant & Animal Science