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Echinococcus: Biology and strain variation
Journal article   Peer reviewed

Echinococcus: Biology and strain variation

R. Thompson and A. Lymbery
International Journal for Parasitology, Vol.20(4), pp.457-470
1990
DOI: https://doi.org/10.1016/0020-7519(90)90193-Q
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Abstract

Biology and strain variation in the causative agent of hydatid disease is reviewed with emphasis on developmental and genetic aspects. In vitro cultivation experiments have made a significant contribution to current knowledge of the developmental plasticity of Echinococcus. However, the mechanisms which regulate and determine developmental strategies in the parasite, as well as the characteristics, source and cytodifferentiation of germinal cells, are not understood. The nature, significance and origin of strain variation in Echinococcus are examined. Before we can fully appreciate the phenotypic consequences of genetic differentiation between populations, we need to know something about the genetic and environmental components of variation in traits such as development rate, host preference, host specificity, virulence and drug resistance. There is an urgent need for research on the developmental pathways by which genetic differences within and between strains of E. granulosus are translated to phenotypic differences in these traits.

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Source: InCites

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53 Times Cited - Web of Science

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Citation topics
1 Clinical & Life Sciences
1.163 Parasitology - General
1.163.1106 Echinococcosis
Web Of Science research areas
Parasitology
ESI research areas
Microbiology
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