Journal article
Economic evaluation of genomic sequencing in the paediatric population: a critical review
European journal of human genetics : EJHG, Vol.26(9), pp.1241-1247
2018
PMCID: PMC6117303
PMID: 29795475
Abstract
Systematic evidence is critical to the formulation of national health policy to provide public funding for the integration of genomic sequencing into routine clinical care. The purpose of this review is to present systematic evidence on the economic evaluation of genomic sequencing conducted for paediatric patients in clinical care, and to identify any gaps in the methodology of economic evaluations. We undertook a critical review of the empirical evidence from economic evaluations of genomic sequencing among paediatric patients searching five electronic databases. Our inclusion criteria were limited to literature published in the English language between 2010 and 2017 in OECD countries. Articles that met our inclusion criteria were assessed using a recognised checklist for a well-designed economic evaluation. We found 11 full-text articles that met our inclusion criteria. Our analysis found that genomic sequencing markedly increased the diagnostic rate to 16–79%, but lowered the cost by 11–64% compared to the standard diagnostic pathway. Only five recent studies in paediatric clinical cohorts met most of the criteria for a well-designed economic evaluation and demonstrated cost-effectiveness of genomic sequencing in paediatric clinical cohorts of patients. Our review identified the need for improvement in the rigour of the methodologies used to provide robust evidence for the formulation of health policy on public funding to integrate genomic sequencing into routine clinical care. Nonetheless, there is emerging evidence of the cost-effectiveness of genomic sequencing over usual care for paediatric patients.
Details
- Title
- Economic evaluation of genomic sequencing in the paediatric population: a critical review
- Authors/Creators
- Khurshid Alam - The University of Western AustraliaDeborah Schofield - Macquarie University
- Publication Details
- European journal of human genetics : EJHG, Vol.26(9), pp.1241-1247
- Publisher
- Springer Nature
- Number of pages
- 7
- Grant note
- Murdoch Children's Research Institute
- Identifiers
- 991005591499407891
- Copyright
- © European Society of Human Genetics 2018
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.189 Genome Studies
- 1.189.597 Genetic Testing
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics