Effect of High-Dose vitamin C on hepatic cytochrome P450 3A4 activity

R.P.G. van Heeswijk; C.L. Cooper; B.C. Foster; B.M. Chauhan; F. Shirazi; I. Seguin; E.J. Phillips; E. Mills

doi:10.1592/phco.2005.25.12.1725

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Effect of High-Dose vitamin C on hepatic cytochrome P450 3A4 activity

Journal article

Peer reviewed

Effect of High-Dose vitamin C on hepatic cytochrome P450 3A4 activity

R.P.G. van Heeswijk, C.L. Cooper, B.C. Foster, B.M. Chauhan, F. Shirazi, I. Seguin, E.J. Phillips and E. Mills

Pharmacotherapy, Vol.25(12), pp.1725-1728

2005

DOI: https://doi.org/10.1592/phco.2005.25.12.1725

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Abstract

Study Objectives. To investigate the effect of high-dose vitamin C on cytochrome P450 (CYP) 3A4 activity, and to evaluate possible sex-specific effects on CYP3A4 activity. Design. Single-center longitudinal study. Setting. Tertiary- and specialty-care teaching hospital. Subjects. Fourteen healthy Caucasian adult volunteers (seven men, seven women). Intervention. Subjects self-administered vitamin C 500 mg twice/day for 14 days. Measurements and Main Results. Hepatic CYP3A4 activity was measured by using the erythromycin breath test on days 1 (baseline) and 15. Overall, no significant effect of vitamin C on CYP3A4 activity was observed. Sex and baseline results were significant predictors of changes in CYP3A4 activity. In men, mean activity increased by 21.9% (95% confidence interval −3.88–47.6%). The effect in women was not consistent. Conclusion. Sex and baseline CYP3A4 activity appeared to influence the effect of vitamin C on CYP3A4 activity.

Details

Title: Effect of High-Dose vitamin C on hepatic cytochrome P450 3A4 activity
Authors/Creators: R.P.G. van Heeswijk (Author/Creator) - Ottawa Hospital
C.L. Cooper (Author/Creator) - Ottawa Hospital
B.C. Foster (Author/Creator) - Health Canada
B.M. Chauhan (Author/Creator) - University of Ottawa
F. Shirazi (Author/Creator) - Ottawa Regional Cancer Centre
I. Seguin (Author/Creator) - Ottawa Hospital
E.J. Phillips (Author/Creator) - AIDS Vancouver
E. Mills (Author/Creator) - Canadian College of Naturopathic Medicine
Publication Details: Pharmacotherapy, Vol.25(12), pp.1725-1728
Publisher: Wiley
Identifiers: 991005546368907891
Copyright: 2005 Pharmacotherapy Publications Inc.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.117 Pharmacology & Toxicology; 1.117.179 Cytochrome P450
Web Of Science research areas: Pharmacology & Pharmacy
ESI research areas: Pharmacology & Toxicology