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Published (Version of Record)CC BY-NC V4.0, Open Access
Journal article
Effect of cimetidine on pharmacokinetics of orally administered cyclosporine in healthy dogs
American journal of veterinary research, Vol.62(7), pp.1046-1050
2001
PMID: 11453478
Abstract
Objective
To describe the pharmacokinetics of cyclosporine (CyA) in healthy dogs after oral administration alone or in combination with orally administered cimetidine.
Animals
10 healthy adult Beagles.
Procedure
Dogs were randomly assigned to receive CyA alone or CyA in combination with cimetidine. After a washout period of 2 weeks, dogs then received the alternate treatment. The CyA plus cimetidine treatment required administration of cimetidine (15 mg/kg of body weight, PO, q 8 h) for 8 days and administration of CyA (5 mg/kg, PO, q 24 h) on days 6 through 8. The CyA treatment alone required administration of CyA (5 mg/kg, PO, q 24 h) for 3 days. On the third day of CyA administration during each treatment, blood samples were collected immediately before (time 0) and 0.5, 1, 1.5, 2, 2.5, 3, 5, 7, 9, 11, 13, 15, 21, and 24 hours after initiating CyA administration.
Results
Time until maximum CyA concentration was significantly longer for CyA in combination with cimetidine. Assessment of estimated pharmacokinetic variables revealed a significantly faster rate of change in the distribution phase for CyA in combination with cimetidine. Maximum CyA concentration differed significantly among dogs but did not differ significantly between treatments.
Conclusions and Clinical Relevance
Analysis of our data suggests that cimetidine may affect absorption of orally administered CyA, but overall, it does not affect the pharmacokinetics of CyA. There is considerable variability in the maximum concentration of CyA among dogs, and monitoring of blood concentrations of CyA during treatment is advised.
Details
- Title
- Effect of cimetidine on pharmacokinetics of orally administered cyclosporine in healthy dogs
- Authors/Creators
- Jenise Coyne Daigle - Louisiana State UniversityGiselle HosgoodCarol S. FoilRobert P. Hunter
- Publication Details
- American journal of veterinary research, Vol.62(7), pp.1046-1050
- Identifiers
- 991005591571407891
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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