Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele

J.A. Jaffey; M. Pavlick; C.R. Webster; G.E. Moore; K.A. McDaniel; S.L. Blois; E.M. Brand; C.F. Reich; L. Motschenbacher; E.T. Hostnik; D. Su; J.A. Lidbury; O. Raab; S.V. Carr; K.E. Mabry; W. Fox-Alvarez; S. Townsend; S. Palermo; Y. Nakazono; K. Ohno; E. VanEerde; H. Fieten; A.H. Hulsman; K. Cooley-Lock; M. Dunning; C. Kisielewicz; A. Zoia; M. Caldin; A. Conti-Patara; L. Ross; C. Mansfield; O. Lynn; M.A. Claus; P.J. Watson; A. Swallow; D.A. Yool; K. Gommeren; M. Knops; V. Ceplecha; H. de Rooster; R. Lobetti; O. Dossin; F. Jolivet; L.G. Papazoglou; M.C.F. Pappalardo; F. Manczur; Z. Dudás-Györki; E.J. O'Neill; C. Martinez; A. Gal; R.L. Owen; E. Gunn; K. Brown; L.K. Harder; C. Griebsch; K.P. Anfinsen; T.K. Gron; V. Marchetti; R.M. Heilmann; P. Pazzi; A.E. DeClue

doi:10.1016/j.tvjl.2019.105350

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Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele

Journal article

Peer reviewed

Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele

J.A. Jaffey, M. Pavlick, C.R. Webster, G.E. Moore, K.A. McDaniel, S.L. Blois, E.M. Brand, C.F. Reich, L. Motschenbacher, E.T. Hostnik, …

The Veterinary Journal, Vol.251, Article number: 105350

2019

DOI: https://doi.org/10.1016/j.tvjl.2019.105350

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Abstract

Gallbladder mucocele (GBM) is a common extra-hepatic biliary syndrome in dogs with death rates ranging from 7 to 45%. Therefore, the aim of this study was to identify the association of survival with variables that could be utilized to improve clinical decisions. A total of 1194 dogs with a gross and histopathological diagnosis of GBM were included from 41 veterinary referral hospitals in this retrospective study. Dogs with GBM that demonstrated abnormal clinical signs had significantly greater odds of death than subclinical dogs in a univariable analysis (OR, 4.2; 95% CI, 2.14-8.23; P < 0.001). The multivariable model indicated that categorical variables including owner recognition of jaundice (OR, 2.12; 95% CI, 1.19-3.77; P = 0.011), concurrent hyperadrenocorticism (OR 1.94; 95% CI, 1.08-3.47; P = 0.026), and Pomeranian breed (OR, 2.46; 95% CI 1.10-5.50; P = 0.029) were associated with increased odds of death, and vomiting was associated with decreased odds of death (OR, 0.48; 95% CI, 0.30-0.72; P = 0.001). Continuous variables in the multivariable model, total serum/plasma bilirubin concentration (OR, 1.03; 95% CI, 1.01-1.04; P < 0.001) and age (OR, 1.17; 95% CI, 1.08-1.26; P < 0.001), were associated with increased odds of death. The clinical utility of total serum/plasma bilirubin concentration as a biomarker to predict death was poor with a sensitivity of 0.61 (95% CI, 0.54-0.69) and a specificity of 0.63 (95% CI, 0.59-0.66). This study identified several prognostic variables in dogs with GBM including total serum/plasma bilirubin concentration, age, clinical signs, concurrent hyperadrenocorticism, and the Pomeranian breed. The presence of hypothyroidism or diabetes mellitus did not impact outcome in this study.

Details

Title: Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele
Authors/Creators: J.A. Jaffey (Author/Creator) - University of Missouri
M. Pavlick (Author/Creator) - Tufts University
C.R. Webster (Author/Creator) - Tufts University
G.E. Moore (Author/Creator) - Purdue University West Lafayette
K.A. McDaniel (Author/Creator) - University of Missouri
S.L. Blois (Author/Creator) - Ontario Veterinary College
E.M. Brand (Author/Creator) - Michigan State University
C.F. Reich (Author/Creator) - Michigan State University
L. Motschenbacher (Author/Creator) - University of Minnesota
E.T. Hostnik (Author/Creator) - The Ohio State University
D. Su (Author/Creator) - University of Tennessee at Knoxville
J.A. Lidbury (Author/Creator) - Texas A&M University
O. Raab (Author/Creator) - University of Prince Edward Island
S.V. Carr (Author/Creator) - Virginia–Maryland College of Veterinary Medicine
K.E. Mabry (Author/Creator) - Virginia–Maryland College of Veterinary Medicine
W. Fox-Alvarez (Author/Creator) - University of Florida
S. Townsend (Author/Creator) - University of Florida
S. Palermo (Author/Creator) - University of Pennsylvania
Y. Nakazono (Author/Creator) - The University of Tokyo
K. Ohno (Author/Creator) - The University of Tokyo
E. VanEerde (Author/Creator) - Iowa State University
H. Fieten (Author/Creator) - Utrecht University
A.H. Hulsman (Author/Creator) - Utrecht University
K. Cooley-Lock (Author/Creator) - Mississippi State University
M. Dunning (Author/Creator) - University of Nottingham
C. Kisielewicz (Author/Creator) - University of Nottingham
A. Zoia (Author/Creator)
M. Caldin (Author/Creator)
A. Conti-Patara (Author/Creator) - Washington State University
L. Ross (Author/Creator) - Auburn University
C. Mansfield (Author/Creator) - The University of Melbourne
O. Lynn (Author/Creator) - The University of Melbourne
M.A. Claus (Author/Creator) - Murdoch University
P.J. Watson (Author/Creator) - University of Cambridge
A. Swallow (Author/Creator) - University of Cambridge
D.A. Yool (Author/Creator) - University of Edinburgh
K. Gommeren (Author/Creator) - University of Liège
M. Knops (Author/Creator) - University of Liège
V. Ceplecha (Author/Creator) - University of Veterinary Sciences Brno
H. de Rooster (Author/Creator) - Ghent University
R. Lobetti (Author/Creator)
O. Dossin (Author/Creator) - Université Fédérale de Toulouse Midi-Pyrénées
F. Jolivet (Author/Creator) - Université Fédérale de Toulouse Midi-Pyrénées
L.G. Papazoglou (Author/Creator) - Aristotle University of Thessaloniki
M.C.F. Pappalardo (Author/Creator)
F. Manczur (Author/Creator) - University of Veterinary Medicine Vienna
Z. Dudás-Györki (Author/Creator) - University of Veterinary Medicine Vienna
E.J. O'Neill (Author/Creator)
C. Martinez (Author/Creator) - University College Dublin
A. Gal (Author/Creator) - Massey University
R.L. Owen (Author/Creator) - Massey University
E. Gunn (Author/Creator) - University of Glasgow
K. Brown (Author/Creator) - University of Glasgow
L.K. Harder (Author/Creator) - University of Veterinary Medicine Vienna
C. Griebsch (Author/Creator) - The University of Sydney
K.P. Anfinsen (Author/Creator)
T.K. Gron (Author/Creator)
V. Marchetti (Author/Creator) - University of Pisa
R.M. Heilmann (Author/Creator) - Leipzig University
P. Pazzi (Author/Creator) - University of Pretoria
A.E. DeClue (Author/Creator)
Publication Details: The Veterinary Journal, Vol.251, Article number: 105350
Publisher: Balliere Tindall
Identifiers: 991005544981307891
Copyright: © 2019 Elsevier Ltd.
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.232 Veterinary Sciences; 3.232.1281 Veterinary Reproductive Health
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science