Effect of hyperbaric oxygen treatment on incorporation of an autogenous cancellous bone graft in a nonunion diaphyseal ulnar defect in cats

Sharon C. Kerwin; Daniel D. Lewis; A. Derrell Elkins; Julian L. Oliver; Giselle Hosgood; Robert D. Pechman; Sharon L. Dial; George M. Strain

doi:10.2460/ajvr.2000.61.691

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Effect of hyperbaric oxygen treatment on incorporation of an autogenous cancellous bone graft in a nonunion diaphyseal ulnar defect in cats

Journal article

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Effect of hyperbaric oxygen treatment on incorporation of an autogenous cancellous bone graft in a nonunion diaphyseal ulnar defect in cats

Sharon C. Kerwin, Daniel D. Lewis, A. Derrell Elkins, Julian L. Oliver, Giselle Hosgood, Robert D. Pechman, Sharon L. Dial and George M. Strain

American journal of veterinary research, Vol.61(6), pp.691-698

2000

DOI: https://doi.org/10.2460/ajvr.2000.61.691

PMID: 10850847

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Abstract

Objective To determine whether hyperbaric oxygen treatment (HBOT) would affect incorporation of an autogenous cancellous bone graft in diaphyseal ulnar defects in cats. Animals 12 mature cats. Procedure Bilateral nonunion diaphyseal ulnar defects were created in each cat. An autogenous cancellous bone graft was implanted in 1 ulnar defect in each cat, with the contralateral ulnar defect serving as a nongrafted specimen. Six cats were treated by use of hyperbaric oxygen at 2 atmospheres absolute for 90 minutes once daily for 14 days, and 6 cats were not treated (control group). Bone labeling was performed, using fluorochrome markers. Cats were euthanatized 5 weeks after implanting, and barium sulfate was infused to evaluate vascularization of grafts. Ulnas were evaluated by use of radiography, microangiography, histologic examination, and histomorphometric examination. Results Radiographic scores did not differ between treatment groups. Microangiographic appearance of grafted defects was similar between groups, with all having adequate vascularization. Differences were not observed between treated and nontreated groups in the overall histologic appearance of decalcified samples of tissue in grafted defects. Mean distance between fluorescent labels was significantly greater in cats given HBOT than in nontreated cats. Median percentage of bone formation in grafted defects was significantly greater in cats given HBOT. Conclusions Hyperbaric oxygen treatment increased the distance between fluorescent labels and percentage of bone formation when incorporating autogenous cancellous bone grafts in induced nonunion diaphyseal ulnar defects in cats, but HBOT did not affect revascularization, radiographic appearance, or qualitative histologic appearance of the grafts.

Details

Title: Effect of hyperbaric oxygen treatment on incorporation of an autogenous cancellous bone graft in a nonunion diaphyseal ulnar defect in cats
Authors/Creators: Sharon C. Kerwin
Daniel D. Lewis
A. Derrell Elkins
Julian L. Oliver
Giselle Hosgood
Robert D. Pechman
Sharon L. Dial
George M. Strain
Publication Details: American journal of veterinary research, Vol.61(6), pp.691-698
Identifiers: 991005592768707891
Murdoch Affiliation: School of Veterinary Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.34 Orthopedics; 1.34.800 Fracture Management
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science