Journal article
Effect of increased physical activity on fructose-induced glycemic response in healthy individuals
European Journal of Clinical Nutrition, Vol.68, pp.1048-1054
2014
Abstract
Background/Objectives: The purpose of the current study was to determine whether increased physical activity (PA) altered glycemic control while ingesting an energy-balanced high-fructose diet.
Subjects/Methods: Twenty-two normal-weight men and women (age: 21.2±0.6 years; body mass index: 22.6 ±0.6 kg/m2) participated in a randomized, cross-over design study in which they ingested an additional 75 g of fructose for 14 days while either maintaining low PA (FR+inactive) (<4500 steps/day) or high PA (FR+active) (>12 000 steps/day). Before and following the 2-week loading period, a fructose-rich meal challenge was administered and blood was sampled at baseline and for 6 h after the meal and analyzed for glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), c-peptide, glucose and insulin concentrations.
Results: Plasma insulin, glucose, c-peptide, GIP and GLP-1 concentrations significantly increased in response to the test meal on all test visits (P<0.05). C-peptide incremental area under the curve (AUC) decreased by 10 208 ±120 pmol/l × min for 6 h from pre to post Fr+active intervention (P=0.02) leading to a decrease in plasma insulin total AUC (pre: 58 470.2±6261.0 pmol/l; post: 49 444.3±3883.0 pmol/l; P=0.04) resulting in a decrease Δpeak[Insulin] (P=0.009). Following the FR+active intervention, GIP total AUC significantly decreased (P=0.005) yet only males had a lower total GLP-1 AUC after both interventions (P=0.049). There were no sex differences in GIP levels.
Conclusions: Increased PA attenuates the deleterious effects on glycemic control caused by a high-fructose diet. These changes in glycemic control with PA are associated with decreases in insulin and GIP concentrations.
Details
- Title
- Effect of increased physical activity on fructose-induced glycemic response in healthy individuals
- Authors/Creators
- A.J. Bidwell (Author/Creator) - State University of New York at OswegoT.J. Fairchild (Author/Creator) - Murdoch UniversityL. Wang (Author/Creator) - California State University, Long BeachS. Keslacy (Author/Creator) - Syracuse UniversityJ.A. Kanaley (Author/Creator) - University of Missouri
- Publication Details
- European Journal of Clinical Nutrition, Vol.68, pp.1048-1054
- Publisher
- Macmillan Publishers Limited.
- Identifiers
- 991005545245807891
- Copyright
- © 2014 Macmillan Publishers Limited
- Murdoch Affiliation
- School of Psychology and Exercise Science
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
25 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.26 Diabetes
- 1.26.831 GLP-1
- Web Of Science research areas
- Nutrition & Dietetics
- ESI research areas
- Clinical Medicine