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Journal article
Effect of inhaled albuterol on whole blood potassium concentrations in dogs
Journal of veterinary internal medicine, Vol.36(6), pp.2002-2008
2022
PMID: 36178135
Abstract
Background: Albuterol by inhalation (IH) is a common treatment for hyperkalemia in humans but its effect on blood potassium concentrations in dogs is unknown.
Objective: Determine whether albuterol (IH) decreases blood potassium concentrations in healthy normokalemic dogs and if effects are dose-dependent.
Animals: Ten healthy dogs.
Methods: Prospective, crossover experimental study. Albuterol sulfate was administered at a low-dose (90 mu g) in phase I and, 7 days later, high-dose (450 mu g) in phase II. Blood potassium and glucose concentrations (measured via blood gas analyzer) and heart rates were obtained at baseline and then 3, 5, 10, 15, 30, 60, 90, 120, 180, and 360 minutes after inhaler actuation.
Results: Blood potassium concentrations decreased rapidly after albuterol delivery with a significant reduction compared to baseline within 30 minutes in both phases (P = .05). The potassium nadir concentration of phase I occurred at 60 minutes (mean, SD; 4.07 mmol/L, 0.4) and was significantly decreased from baseline, (4.30 mmol/L, 0.3; t(9) = 2.40, P = .04). The potassium nadir concentration of phase II occurred at 30 minutes (mean, SD; 3.96 mmol/L, 0.39) and was also significantly decreased from baseline, (4.33 mmol/L, 0.4; t(9) = 2.22, P = .05). The potassium nadir concentration decreased by 0.1 mmol/L for each 10 mu g/kg increase in dose of albuterol (P = .01). Five dogs had >= 1 hyperglycemic measurement (ie, >112 mg/dL). No median heart rate was tachycardic nor was any mean blood glucose concentration hyperglycemic at any time point.
Conclusion and Clinical Importance: Albuterol IH decreases blood potassium concentrations in a dose-dependent manner without clinically meaningful alterations to heart rate or blood glucose concentrations in healthy dogs. The mean decrease in potassium concentration at the high-dose of albuterol was modest (0.38 mmol/L).
Details
- Title
- Effect of inhaled albuterol on whole blood potassium concentrations in dogs
- Authors/Creators
- Andrezej Ogrodny - Midwestern UniversityJared A. Jaffey - Midwestern UniversityRachael Kreisler - Midwestern UniversityMark Acierno - Midwestern UniversityTeela Jones - Midwestern UniversityRenata S. Costa - Midwestern State UniversityAnderson da Cunha - Midwestern UniversityEmily Westerback - Midwestern University
- Publication Details
- Journal of veterinary internal medicine, Vol.36(6), pp.2002-2008
- Publisher
- Wiley
- Number of pages
- 7
- Identifiers
- 991005593762407891
- Copyright
- © 2022 The Authors.
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.55 Urology & Nephrology - General
- 1.55.2271 Hyperkalemia
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science