Journal article
Effect of low-dose zearalenone exposure on reproductive capacity of male mice
Toxicology and Applied Pharmacology, Vol.333, pp.60-67
2017
Abstract
Zearalenone (ZEA), a kind of nonsteroidal mycotoxin with estrogenic effects, can influence animal reproductive capacity through interfering with estrogen signaling pathway. Previous studies have shown exposure to ZEA at high doses (higher than No-Observed Effect Level, NOEL) had a significant impact on mouse sperm quality and pregnant rate, but little is known about the effect of exposure to ZEA at low doses (lower than NOEL) on mouse reproductive capacity. This study evaluated the effects of exposure to low-dose ZEA on mouse spermatogenesis and semen quality. Male mice (CD-1) of 21days were exposed to ZEA at 20, or 40μg/kg body weight for 14, 28 or 42days. After exposure to ZEA for 14days, the spermatogenic cells in seminiferous tubules were declined dose-independently; however in groups treated by ZEA for 28days, the spermatogenic cells were declined dose-dependently. Moreover, after treatment for 28days or 42days, the DNA double stand break (DSB) in spermatogenic cells were increased in a dose-dependent manner in treated groups. Compared with the control group, the sperm concentration, viability, motility, and hyperactive rate in treated groups were decreased dose-dependently and time-dependently. Meanwhile, deformity and mortality rate of sperm in treated groups were increased remarkably dose-dependently too. In conclusion, low dose ZEA impaired male reproductive capacity especially in spermatogenesis and semen quality of mouse.
Details
- Title
- Effect of low-dose zearalenone exposure on reproductive capacity of male mice
- Authors/Creators
- J. Pang (Author/Creator)Q. Zhou (Author/Creator)X. Sun (Author/Creator)L. Li (Author/Creator)B. Zhou (Author/Creator)F. Zeng (Author/Creator)Y. Zhao (Author/Creator)W. Shen (Author/Creator)Z. Sun (Author/Creator)
- Publication Details
- Toxicology and Applied Pharmacology, Vol.333, pp.60-67
- Publisher
- Elsevier
- Identifiers
- 991005544899307891
- Copyright
- © 2017 Elsevier Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.198 Mycotoxins
- 3.198.400 Mycotoxin Control
- Web Of Science research areas
- Pharmacology & Pharmacy
- Toxicology
- ESI research areas
- Pharmacology & Toxicology