Effect of multipurpose solutions for contact lens care on the in vitro drug-induced spoliation of poly(2-hydroxyethyl methacrylate) in simulated aqueous humour

T.V. Chirila; D.A. Morrison; Z. Gridneva; D. Meyrick; C.R. Hicks; J.M. Webb

doi:10.1016/j.clae.2004.09.004

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Effect of multipurpose solutions for contact lens care on the in vitro drug-induced spoliation of poly(2-hydroxyethyl methacrylate) in simulated aqueous humour

Journal article

Peer reviewed

Effect of multipurpose solutions for contact lens care on the in vitro drug-induced spoliation of poly(2-hydroxyethyl methacrylate) in simulated aqueous humour

T.V. Chirila, D.A. Morrison, Z. Gridneva, D. Meyrick, C.R. Hicks and J.M. Webb

Contact Lens and Anterior Eye, Vol.28(1), pp.21-28

2005

DOI: https://doi.org/10.1016/j.clae.2004.09.004

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Abstract

Drug-induced spoliation of hydrogels as contact lenses or as implants in the anterior eye is a frequent occurrence in clinical practice. This study explores the capacity of three commercial multipurpose solutions for contact lens care to reduce the spoliation of poly(2-hydroxyethyl methacrylate) (PHEMA) specimens exposed to a simulated aqueous humour formulation and to three topical drugs commonly administered after insertion of artificial corneas (Predsol, Optimol and Depo-Ralovera). ReNu MultiPlus® (Bausch & Lomb), Complete® Blink-N-Clean™ Lens Drops (Allergan) and Complete Protein Remover Tablets dissolved in Complete® ComfortPLUS™ (both from Allergan) were evaluated. All multipurpose solutions were able to dislodge passively the deposits formed on hydrogels in the simulated aqueous and in the presence of Predsol and Optimol, but none were effective against the deposits induced by Depo-Ralovera. A reduction of the calcium content in deposits caused by Predsol and Optimol was confirmed after treatment with the protein remover preparation, while the other multipurpose solutions caused the complete removal of the deposits. In experiments designed to evaluate the preventive action of the multipurpose solutions, no such effects were observed regardless of the drug involved. The prospect of using multipurpose solutions as eye drops following implantation of a hydrogel artificial cornea is a valid alternative for reducing device spoliation, however it appears to depend on the nature of the postoperative medication.

Details

Title: Effect of multipurpose solutions for contact lens care on the in vitro drug-induced spoliation of poly(2-hydroxyethyl methacrylate) in simulated aqueous humour
Authors/Creators: T.V. Chirila (Author/Creator)
D.A. Morrison (Author/Creator)
Z. Gridneva (Author/Creator)
D. Meyrick (Author/Creator)
C.R. Hicks (Author/Creator)
J.M. Webb (Author/Creator)
Publication Details: Contact Lens and Anterior Eye, Vol.28(1), pp.21-28
Publisher: Elsevier
Identifiers: 991005543286607891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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