Journal article
Effect of saffron supplementation on symptoms of depression and anxiety: A systematic review and meta-analysis
Nutrition Reviews, Vol.77(8), pp.557-571
2019
Abstract
CONTEXT:
Saffron (Crocus sativus L.) has gained interest as a potential treatment in psychiatry.
OBJECTIVE:
This systematic review and meta-analysis sought to investigate the effect of saffron supplementation, as both an adjunctive therapy and monotherapy, on symptoms of depression and anxiety in clinical and general populations compared with pharmacotherapy or placebo.
DATA SOURCES:
Using the PRISMA guidelines, a systematic literature review of randomized controlled trials was conducted.
DATA EXTRACTION:
A meta-analysis was conducted to determine treatment effect. Risk of bias was assessed using the Jadad scale.
RESULTS:
Twenty-three studies were included. Saffron had a large positive effect size when compared with placebo for depressive symptoms (g = 0.99, P < 0.001) and anxiety symptoms (g = 0.95, P < 0.006). Saffron also had a large positive effect size when used as an adjunct to antidepressants for depressive symptoms (g = 1.23, P = 0.028). Egger's regression test found evidence of publication bias.
CONCLUSIONS:
Saffron could be an effective intervention for symptoms of depression and anxiety; however, due to evidence of publication bias and lack of regional diversity, further trials are required. PROSPERO registration CRD42017070060.
Details
- Title
- Effect of saffron supplementation on symptoms of depression and anxiety: A systematic review and meta-analysis
- Authors/Creators
- W. Marx (Author/Creator) - Deakin UniversityM. Lane (Author/Creator) - Deakin UniversityT. Rocks (Author/Creator) - Deakin UniversityA. Ruusunen (Author/Creator) - University of Eastern FinlandA. Loughman (Author/Creator) - Deakin UniversityA. Lopresti (Author/Creator) - Murdoch UniversityS. Marshall (Author/Creator) - Bond UniversityM. Berk (Author/Creator) - The University of MelbourneF. Jacka (Author/Creator) - Murdoch Children's Research InstituteO.M. Dean (Author/Creator) - Florey Institute of Neuroscience and Mental Health
- Publication Details
- Nutrition Reviews, Vol.77(8), pp.557-571
- Publisher
- Oxford University Press on behalf of the International Life Sciences Institute
- Identifiers
- 991005543252507891
- Copyright
- © The Author(s) 2019
- Murdoch Affiliation
- School of Psychology and Exercise Science
- Language
- English
- Resource Type
- Journal article
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