Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations

T. Rouxel; J. Grandaubert; J.K. Hane; C. Hoede; A.P. van de Wouw; A. Couloux; V. Dominguez; V. Anthouard; P. Bally; S. Bourras; A.J. Cozijnsen; L.M. Ciuffetti; A. Degrave; A. Dilmaghani; L. Duret; I. Fudal; S.B. Goodwin; L. Gout; N. Glaser; J. Linglin; G.H.J. Kema; N. Lapalu; C.B. Lawrence; K. May; M. Meyer; B. Ollivier; Julie Poulain; Conrad L. Schoch; A. Simon; J.W. Spatafora; A. Stachowiak; B.G. Turgeon; B.M. Tyler; D. Vincent; J. Weissenbach; J. Amselem; H. Quesneville; R.P. Oliver; P. Wincker; M-H. Balesdent; B.J. Howlett

doi:10.1038/ncomms1189

Back

Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations

Journal article

Open access

Peer reviewed

Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations

T. Rouxel, J. Grandaubert, J.K. Hane, C. Hoede, A.P. van de Wouw, A. Couloux, V. Dominguez, V. Anthouard, P. Bally, S. Bourras, …

Nature Communications, Vol.2(1)

2011

DOI: https://doi.org/10.1038/ncomms1189

Files and links (2)

pdf

effector_diversification.pdfDownload View

Published (Version of Record) Open Access

url

Free to Read *No subscription requiredView

Abstract

Fungi are of primary ecological, biotechnological and economic importance. Many fundamental biological processes that are shared by animals and fungi are studied in fungi due to their experimental tractability. Many fungi are pathogens or mutualists and are model systems to analyse effector genes and their mechanisms of diversification. In this study, we report the genome sequence of the phytopathogenic ascomycete Leptosphaeria maculans and characterize its repertoire of protein effectors. The L. maculans genome has an unusual bipartite structure with alternating distinct guanine and cytosine-equilibrated and adenine and thymine (AT)-rich blocks of homogenous nucleotide composition. The AT-rich blocks comprise one-third of the genome and contain effector genes and families of transposable elements, both of which are affected by repeat-induced point mutation, a fungal-specific genome defence mechanism. This genomic environment for effectors promotes rapid sequence diversification and underpins the evolutionary potential of the fungus to adapt rapidly to novel host-derived constraints.

Details

Title: Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations
Authors/Creators: T. Rouxel (Author/Creator)
J. Grandaubert (Author/Creator)
J.K. Hane (Author/Creator)
C. Hoede (Author/Creator)
A.P. van de Wouw (Author/Creator)
A. Couloux (Author/Creator)
V. Dominguez (Author/Creator)
V. Anthouard (Author/Creator)
P. Bally (Author/Creator)
S. Bourras (Author/Creator)
A.J. Cozijnsen (Author/Creator)
L.M. Ciuffetti (Author/Creator)
A. Degrave (Author/Creator)
A. Dilmaghani (Author/Creator)
L. Duret (Author/Creator)
I. Fudal (Author/Creator)
S.B. Goodwin (Author/Creator)
L. Gout (Author/Creator)
N. Glaser (Author/Creator)
J. Linglin (Author/Creator)
G.H.J. Kema (Author/Creator)
N. Lapalu (Author/Creator)
C.B. Lawrence (Author/Creator)
K. May (Author/Creator)
M. Meyer (Author/Creator)
B. Ollivier (Author/Creator)
Julie Poulain (Author/Creator)
Conrad L. Schoch (Author/Creator)
A. Simon (Author/Creator)
J.W. Spatafora (Author/Creator)
A. Stachowiak (Author/Creator)
B.G. Turgeon (Author/Creator)
B.M. Tyler (Author/Creator)
D. Vincent (Author/Creator)
J. Weissenbach (Author/Creator)
J. Amselem (Author/Creator)
H. Quesneville (Author/Creator)
R.P. Oliver (Author/Creator)
P. Wincker (Author/Creator)
M-H. Balesdent (Author/Creator)
B.J. Howlett (Author/Creator)
Publication Details: Nature Communications, Vol.2(1)
Identifiers: 991005540915007891
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article
Note: This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

257 File views/ downloads

77 Record Views

387 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.4 Crop Science; 3.4.419 Jasmonic Acid
Web Of Science research areas: Biochemistry & Molecular Biology
ESI research areas: Plant & Animal Science