Journal article
Effects of CCR5-Δ 32, CCR2-64I, and SDF-1 3′A Alleles on HIV-1 Disease Progression: An International Meta-Analysis of Individual-Patient Data
Annals of Internal Medicine, Vol.135(9), pp.782-795
2001
Abstract
The burgeoning information on the human genome creates opportunities and challenges for studies of disease associations. Because genetic differences often produce modest effects, many patients must be studied to reach definitive conclusions. In the absence of a single large study, meta-analysis of individual-patient data (1 - 3) from smaller studies offers a way to assemble an adequate sample size. This approach is based on a unifying protocol that has standardized analytic definitions. When the protocol is applied to data contributed by most investigators working in a field, this method can provide more convincing results than a simple pooling of data or a meta-analysis of published reports (3). A meta-analysis of individual-patient data is also superior to a meta-analysis of published reports for examining differences in reported results.
Details
- Title
- Effects of CCR5-Δ 32, CCR2-64I, and SDF-1 3′A Alleles on HIV-1 Disease Progression: An International Meta-Analysis of Individual-Patient Data
- Authors/Creators
- J.P.A. Ioannidis (Author/Creator) - National Institutes of HealthP.S. Rosenberg (Author/Creator) - National Institutes of HealthJ.J. Goedert (Author/Creator) - National Institutes of HealthL.J. Ashton (Author/Creator) - National Institutes of HealthT.L. Benfield (Author/Creator) - National Institutes of HealthS.P. Buchbinder (Author/Creator) - National Institutes of HealthR.A. Coutinho (Author/Creator) - National Institutes of HealthJ. Eugen-Olsen (Author/Creator) - National Institutes of HealthT. Gallart (Author/Creator) - National Institutes of HealthT.L. Katzenstein (Author/Creator) - National Institutes of HealthL.G. Kostrikis (Author/Creator) - National Institutes of HealthH. Kuipers (Author/Creator) - National Institutes of HealthL.G. Louie (Author/Creator) - National Institutes of HealthS.A. Mallal (Author/Creator) - National Institutes of HealthJ.B. Margolick (Author/Creator) - National Institutes of HealthO.P. Martinez (Author/Creator) - National Institutes of HealthL. Meyer (Author/Creator) - National Institutes of HealthN.L. Michael (Author/Creator) - National Institutes of HealthE. Operskalski (Author/Creator) - National Institutes of HealthG. Pantaleo (Author/Creator) - National Institutes of HealthG.P. Rizzardi (Author/Creator) - National Institutes of HealthH. Schuitemaker (Author/Creator) - National Institutes of HealthH.W. Sheppard (Author/Creator) - National Institutes of HealthG.J. Stewart (Author/Creator) - National Institutes of HealthI.D. Theodorou (Author/Creator) - National Institutes of HealthH. Ullum (Author/Creator) - National Institutes of HealthE. Vicenzi (Author/Creator) - National Institutes of HealthD. Vlahov (Author/Creator) - National Institutes of HealthD. Wilkinson (Author/Creator) - National Institutes of HealthC. Workman (Author/Creator) - National Institutes of HealthJ-F Zagury (Author/Creator) - National Institutes of HealthT.R. O'Brien (Author/Creator) - National Institutes of Health
- Publication Details
- Annals of Internal Medicine, Vol.135(9), pp.782-795
- Publisher
- American College of Physicians
- Identifiers
- 991005544147207891
- Copyright
- 2001 American College of Physicians/American Society of Internal Medicine
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.46 HIV Pathogenesis
- Web Of Science research areas
- Immunology
- ESI research areas
- Clinical Medicine