Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study

A.L. Lopresti; S.J. Smith; S. Ali; A.P. Metse; J. Kalns; P.D. Drummond

doi:10.1016/j.jff.2021.104671

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Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study

Journal article

Open access

Peer reviewed

Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study

A.L. Lopresti, S.J. Smith, S. Ali, A.P. Metse, J. Kalns and P.D. Drummond

Journal of Functional Foods, Vol.85, Art. 104671

2021

DOI: https://doi.org/10.1016/j.jff.2021.104671

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Abstract

In this 28-day, randomised, double-blind, placebo-controlled trial, 100 adults with self-reported poor sleep received either a placebo or a standardised Bacopa monnieri extract (150 mg twice daily). Outcome measures included the Bergen Insomnia Scale (primary outcome measure), Functional Outcomes of Sleep Questionnaire, Pittsburgh Sleep Diary, Short Form-36 Health Survey, and the Depression, Anxiety, and Stress Scale. Changes in salivary concentrations of cortisol, dehydroepiandrosterone sulfate, immunoglobulin A (sIgA), α-amylase (sAA), C-reactive protein, melatonin, and the fatigue biomarker index were also assessed. Based on the Bergen Insomnia Scale, Bacopa monnieri did not improve sleep patterns more than the placebo; however, it was associated with greater improvements in emotional wellbeing, general health, and pain-related symptoms. Bacopa monnieri was also associated with greater reductions in sIgA and sAA compared to the placebo. Future clinical trials using varying doses, treatment periods, and objective outcome measures will be important to validate these findings.

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Title: Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study
Authors/Creators: A.L. Lopresti (Author/Creator) - Murdoch University
S.J. Smith (Author/Creator) - Murdoch University
S. Ali (Author/Creator) - Salpath Functional Pathology, Sydney, New South Wales 2016, Australia
A.P. Metse (Author/Creator) - University of the Sunshine Coast
J. Kalns (Author/Creator) - Hyperion (Ireland)
P.D. Drummond (Author/Creator) - Murdoch University
Publication Details: Journal of Functional Foods, Vol.85, Art. 104671
Publisher: Elsevier Ltd.
Identifiers: 991005540229007891
Copyright: © 2021 Published by Elsevier Ltd.
Murdoch Affiliation: Centre for Healthy Ageing
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.16 Phytochemicals; 3.16.2410 Medicinal Plant Extracts
Web Of Science research areas: Food Science & Technology; Nutrition & Dietetics
ESI research areas: Agricultural Sciences