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Journal article
Effects of dietary nanoliposome-coated astaxanthin on haematological parameters, immune responses and the antioxidant status of rainbow trout (Oncorhynchus mykiss)
Veterinary medicine and science, Vol.10(3), e1461
2024
PMID: 38648257
Abstract
Background
Astaxanthin is the most prevalent carotenoid in the marine environment and is widely used as an additive in formulated aquafeeds.
Objectives
A 60-day feeding trial was conducted to consider the effect of dietary nanoliposome-coated astaxanthin (NA) on haematological parameters, serum antioxidant activities and immune responses of rainbow trout, Oncorhynchus mykiss.
Methods
A total of 450 healthy fish weighing 31.00 ± 2.09 g were randomly assigned in triplicate (30 fish per replicate) to 5 dietary treatments: 0 (control), 25.00, 50.00, 75.00, and 100.00 mg kg−1 NA.
Results
Fish fed the diet supplemented with 50.00 mg kg−1 NA exhibited the highest values of red blood cells, white blood cells, haemoglobin and haematocrit of 1.64 ± 0.01 × 106 mm−3, 5.54 ± 0.21 × 103 mm−3, 8.73 ± 0.24 g dL−1 and 46.67% ± 0.88%, respectively, which were significantly higher than those fed the basal diet (p < 0.05). The lowest and highest percentages of lymphocytes (67.67% ± 0.33%) and neutrophils (27.33% ± 1.20%) were also obtained in fish fed 50.00 mg kg−1 NA compared to those fed the basal diet (p < 0.05). Fish receiving diet supplemented with 50.00 mg kg−1 NA revealed the highest serum activity in superoxide dismutase, catalase, glutathione peroxidase, lysozyme and alternative complement and the lowest level of total cholesterol, cortisol, aspartate aminotransferase and alanine aminotransferase than fish receiving the basal diet (p < 0.05). Serum immunoglobulin (Ig) and ACH50 contents significantly increased with increasing dietary NA supplementation to the highest values of 43.17 ± 1.46 and 293.33 ± 2.03 U mL−1, respectively, in fish fed diet supplemented with 50 mg kg−1 NA (p < 0.05).
Conclusions
Supplementation of NA in rainbow trout diet at 50 mg kg−1 exhibited a positive effect on haematological parameters, antioxidant capacity and immune responses. Administration of such dosage can enhance rainbow trout immune responses against unfavourable or stressful conditions, for example disease outbreaks, hypoxic condition, thermal stress and sudden osmotic fluctuations, which usually happen in an intensive culture system.
Details
- Title
- Effects of dietary nanoliposome-coated astaxanthin on haematological parameters, immune responses and the antioxidant status of rainbow trout (Oncorhynchus mykiss)
- Authors/Creators
- Mojdeh Besharat - Islamic Azad University, Science and Research BranchHouman Rajabi Islami - Islamic Azad University, Science and Research BranchMehdi Soltani - Centre for Sustainable Aquatic Ecosystems, Harry Butler Institute, School of Veterinary and Life Science, Murdoch University, Murdoch, AustraliaSeyed Abdolmajid Mousavi - Islamic Azad University of Varamin
- Publication Details
- Veterinary medicine and science, Vol.10(3), e1461
- Publisher
- John Wiley & Sons Ltd.
- Grant note
- Islamic Azad University
- Identifiers
- 991005657666607891
- Copyright
- © 2024 The Authors.
- Murdoch Affiliation
- Centre for Sustainable Aquatic Ecosystems
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.2 Marine Biology
- 3.2.116 Aquaculture Nutrition
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science