Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs

Casey J LeBlanc; David W Horohov; John E Bauer; Giselle Hosgood; Glenna E Mauldin

doi:10.2460/ajvr.69.4.486

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Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs

Journal article

Open access

Peer reviewed

Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs

Casey J LeBlanc, David W Horohov, John E Bauer, Giselle Hosgood and Glenna E Mauldin

American journal of veterinary research, Vol.69(4), pp.486-493

2008

DOI: https://doi.org/10.2460/ajvr.69.4.486

PMID: 18380580

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Abstract

Objective To evaluate the effect of diets enriched with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on in vivo production of interleukin (IL)-1, IL-6, tumor necrosis factor (TNF)-α, prostaglandin E2 (PGE2), and platelet-activating factor (PAF) in dogs. Animals 15 young healthy dogs. Procedures Dogs were randomly allocated to receive an isocaloric ration supplemented with sunflower oil (n = 5), fish oil (5), or fish oil plus vitamin E (5) for 12 weeks. At week 12, in vivo production of inflammatory mediators was evaluated in serum at multiple time points for 6 hours following stimulation with IV administration of lipopolysaccharide (LPS). Results Serum activity or concentration (area under the curve) of IL-1, IL-6, and PGE2 significantly increased after LPS injection in all groups but to a lesser extent in dogs receiving the fish oil diet, compared with results for dogs receiving the sunflower oil diet. Serum activity of TNF-α and PAF concentration also increased significantly after LPS injection in all groups but did not differ significantly among groups. Conclusions and Clinical Relevance A fish oil–enriched diet consisting of 1.75 g of EPA/kg of diet and 2.2 g of DHA/kg of diet (dry-matter basis) with an n-6:n-3 fatty acid ratio of 3.4:1 was associated with significant reductions in serum PGE2 concentrations and IL-1 and IL-6 activities. Results supported the use of EPA- and DHA-enriched diets as part of antiinflammatory treatments for dogs with chronic inflammatory diseases. Additional studies in affected dogs are warranted to further evaluate beneficial anti-inflammatory effects of EPA- and DHA-enriched diets.

Details

Title: Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs
Authors/Creators: Casey J LeBlanc - Louisiana State University
David W Horohov
John E Bauer
Giselle Hosgood
Glenna E Mauldin
Publication Details: American journal of veterinary research, Vol.69(4), pp.486-493
Identifiers: 991005592770307891
Murdoch Affiliation: School of Veterinary Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.68 Lipids; 1.68.256 Fatty Acids
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science