Journal article
Effects of different exercise modalities on fatigue in prostate cancer patients undergoing androgen deprivation therapy: A year-long randomised controlled trial
European Urology, Vol.In press
2017
Abstract
Background: Physical exercise mitigates fatigue during androgen deprivation therapy (ADT); however, the effects of different exercise prescriptions are unknown.
Objectives: To determine the long-term effects of different exercise modes on fatigue in prostate cancer patients undergoing ADT.
Design, setting, and participants: Between 2009 and 2012, 163 prostate cancer patients aged 43-90 y on ADT were randomised to exercise targeting the musculoskeletal system (impact loading + resistance training; ILRT; n = 58), the cardiovascular and muscular systems (aerobic + resistance training; ART; n = 54), or to usual care/delayed exercise (DEL; n = 51) for 12 mo across university-affiliated exercise clinics in Australia.
Intervention: Supervised ILRT for 12 mo, supervised ART for 6 mo followed by a 6-mo home program, and DEL received a printed booklet on exercise information for 6 mo followed by 6-mo stationary cycling exercise. Outcome measurements and statistical analysis: Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 36 and vitality using the Short Form-36. Analysis of variance was used to compare outcomes for groups at 6 mo and 12 mo.
Results and limitations: Fatigue was reduced (p =0.005) in ILRT at 6 mo and 12 mo (∼5 points), and in ART (p =0.005) and DEL (p =0.022) at 12 mo. Similarly, vitality increased for all groups (p ≤0.001) at 12 mo (∼4 points). Those with the highest levels of fatigue and lowest vitality improved the most with exercise (p trend <0.001). A limitation was inclusion of mostly well-functioning individuals.
Conclusions: Different exercise modes have comparable effects on reducing fatigue and enhancing vitality during ADT. Patients with the highest levels of fatigue and lowest vitality had the greatest benefits.
Patient summary: We compared the effects of different exercise modes on fatigue in men on androgen deprivation therapy. All exercise programs reduced fatigue and enhanced vitality. We conclude that undertaking some form of exercise will help reduce fatigue, especially in those who are the most fatigued. We compared the effects of different exercise modes on fatigue in men on androgen deprivation therapy. All exercise programs reduced fatigue and enhanced vitality. We conclude that undertaking some form of exercise will help reduce fatigue, especially in those who are the most fatigued.
Details
- Title
- Effects of different exercise modalities on fatigue in prostate cancer patients undergoing androgen deprivation therapy: A year-long randomised controlled trial
- Authors/Creators
- D.R. Taaffe (Author/Creator) - The University of QueenslandR.U. Newton (Author/Creator) - University of Hong KongN. Spry (Author/Creator) - Edith Cowan UniversityD. Joseph (Author/Creator) - The University of Western AustraliaS.K. Chambers (Author/Creator) - Prostate Cancer Foundation of AustraliaR.A. Gardiner (Author/Creator) - Royal Brisbane and Women's HospitalB.A. Wall (Author/Creator) - Edith Cowan UniversityP. Cormie (Author/Creator) - Australian Catholic UniversityK.A. Bolam (Author/Creator) - Swedish School of Sport and Health SciencesD.A. Galvão (Author/Creator) - Edith Cowan University
- Publication Details
- European Urology, Vol.In press
- Publisher
- Elsevier
- Identifiers
- 991005541493607891
- Copyright
- © 2017 European Association of Urology
- Murdoch Affiliation
- School of Psychology and Exercise Science
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
93 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.112 Palliative Care
- 1.112.297 Cancer Survivors
- Web Of Science research areas
- Urology & Nephrology
- ESI research areas
- Clinical Medicine