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Journal article
Effects of pregnancy and lactation prebiotics supplementation on infant allergic disease: a randomized controlled trial.
Journal of Allergy and Clinical Immunology
2024
Abstract
Background
Ingestion of prebiotics during pregnancy and lactation may have immunomodulatory benefits for the developing fetal and infant immune system and provide a potential dietary strategy to reduce the risk of allergic diseases.
Objective
We sought to determine whether maternal supplementation with dietary prebiotics reduces the risk of allergic outcomes in infants with hereditary risk.
Methods
We undertook a double-blind randomized controlled trial in which pregnant women were allocated to consume prebiotics (14.2 g daily of galacto-oligosaccharides and fructo-oligosaccharides in the ratio 9:1) or placebo (8.7 g daily of maltodextrin) powder from less than 21 weeks’ gestation until 6 months postnatal during lactation. Eligible women had infants with a first-degree relative with a history of medically diagnosed allergic disease. The primary outcome was medically diagnosed infant eczema by age 1 year, and secondary outcomes included allergen sensitization, food allergy, and recurrent wheeze by age 1 year.
Results
A total of 652 women were randomized between June 2016 and November 2021 (329 in the prebiotics group and 323 in the placebo group). There was no significant difference between groups in the percentage of infants with medically diagnosed eczema by age 1 year (prebiotics 31.5% [103 of 327 infants] vs placebo 32.6% [105 of 322 infants]; adjusted relative risk, 0.98; 95% CI, 0.77-1.23; P = .84). Secondary outcomes and safety measures also did not significantly differ between groups.
Conclusions
We found little evidence that maternal prebiotics supplementation during pregnancy and lactation reduces the risk of medically diagnosed infant eczema by age 1 year in infants who are at hereditary risk of allergic disease.
Details
- Title
- Effects of pregnancy and lactation prebiotics supplementation on infant allergic disease: a randomized controlled trial.
- Authors/Creators
- Debra J. Palmer - The Kids Research Institute AustraliaAlana R. Cuthbert - South Australian Health and Medical Research InstituteThomas R. Sullivan - South Australian Health and Medical Research InstituteRachelle Ann Pretorius - Murdoch University, School of Medical, Molecular and Forensic SciencesJohan GarssenK. Rueter - Princess Margaret Hospital for ChildrenMaria C. JenmalmJeffrey Keelan - The University of Western AustraliaDesiree T Silva - The University of Western AustraliaSusan L. Prescott - Murdoch University
- Publication Details
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.
- Identifiers
- 991005701669607891
- Copyright
- © 2024 The Authors.
- Murdoch Affiliation
- School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
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