Files and links (1)
Published (Version of Record)CC BY V4.0, Open Access
Journal article
Effects of short-term exercise on plasma metabolic and lipidomic profiles of individuals with type 2 diabetes
Experimental physiology, Early view
2025
PMID: 40551391
Abstract
Type 2 diabetes mellitus (T2DM) is a common metabolic disorder characterized by chronic hyperglycaemia, with physical inactivity and excessive adiposity as predisposing factors. This clinical trial aimed to investigate the effects of an exercise intervention on the metabolome of T2DM participants, fasting and in response to an oral glucose tolerance test (OGTT) and an acute exercise stimulus. Thirteen people with T2DM (age 51 ± 7 years; body mass index 32.7 ± 4.9 kg/m2) completed 45 min of moderate-intensity treadmill exercise on 12 days consecutively. Blood samples were collected before and after the first and last training sessions and during a pre- and postintervention OGTT. Fasted blood samples were collected from 198 healthy control subjects and 208 people with T2DM from an independent cohort for comparison. Samples were analysed using high-resolution 1H nuclear magnetic resonance spectroscopy and liquid chromatography–mass spectrometry. The exercise intervention did not induce a shift towards a healthier fasted metabolome in people living with T2DM. In response to consumption of a glucose bolus (OGTT), glycolysis-related metabolites increased and free fatty acids decreased, with no effect of the exercise intervention. In response to acute exercise, glucose and amino acids decreased and free fatty acids increased, with similar responses on the last day of training as on the first day, indicating no effect of the intervention. The clinical trial was registered prospectively in the Australian New Zealand Clinical Trials Registry ACTRN12617000286347 on 24 February 2017.
Details
- Title
- Effects of short-term exercise on plasma metabolic and lipidomic profiles of individuals with type 2 diabetes
- Authors/Creators
- Maartje Cox - Harry Perkins Institute of Medical ResearchAaron Raman - Murdoch UniversityTimothy Fairchild - Murdoch UniversityJohn P Beilby - The University of Western AustraliaBu B Yeap - Fiona Stanley HospitalJeremy K Nicholson - Imperial College LondonJulien Wist - Universidad del ValleJeremiah Peiffer - Murdoch UniversityNathan G Lawler - Harry Perkins Institute of Medical Research
- Publication Details
- Experimental physiology, Early view
- Publisher
- WILEY
- Number of pages
- 29
- Grant note
- German Academic Exchange Service (DAAD) Bruker BioSpin Murdoch University
- Identifiers
- 991005787853607891
- Copyright
- © 2025 The Author(s).
- Murdoch Affiliation
- Research and Innovation Office; Centre for Healthy Ageing; Health Futures Institute; Personalised Medicine Centre; School of Allied Health; Centre for Computational and Systems Medicine
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Metrics
5 File views/ downloads
26 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 2 Chemistry
- 2.211 Mass Spectrometry
- 2.211.990 Metabolomics
- Web Of Science research areas
- Physiology
- ESI research areas
- Biology & Biochemistry