Effects of theophylline on the activation and nuclear translocation of the hepatic glucocorticoid receptor at low temperature

M.H. Cake; G. Litwack

doi:10.1016/0006-291X(75)90584-7

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Effects of theophylline on the activation and nuclear translocation of the hepatic glucocorticoid receptor at low temperature

Journal article

Peer reviewed

Effects of theophylline on the activation and nuclear translocation of the hepatic glucocorticoid receptor at low temperature

M.H. Cake and G. Litwack

Biochemical and Biophysical Research Communications, Vol.66(2), pp.828-835

1975

DOI: https://doi.org/10.1016/0006-291X(75)90584-7

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Abstract

In Vitro nuclear binding of the (3H) dexamethasone-receptor complex from rat liver cytosol takes place at a slow rate when nuclei are incubated at low temperature. However, if theophylline is included during the incubation there is a threefold increase in the rate of nuclear binding. The activation by theophylline is independent of its known effect on cyclic AMP levels since the cyclic nucleotide has no effect on nuclear binding either in the absence or presence of theophylline. Activation ability is specific to methylxanthines and not to nucleoside derivatives. Theophylline may be acting directly on the (3H) dexamethasone-receptor complex converting it to an active form.

Details

Title: Effects of theophylline on the activation and nuclear translocation of the hepatic glucocorticoid receptor at low temperature
Authors/Creators: M.H. Cake (Author/Creator) - Temple University
G. Litwack (Author/Creator) - Temple University
Publication Details: Biochemical and Biophysical Research Communications, Vol.66(2), pp.828-835
Publisher: Elsevier Inc.
Identifiers: 991005544551507891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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