Journal article
Efficacy of albendazole against Giardia and hookworm in a remote Aboriginal community in the north of Western Australia
Acta Tropica, Vol.71(1), pp.27-44
1998
Abstract
The parasitological, clinical efficacy and tolerability of albendazole in the treatment for both giardiasis and hookworm infection in a remote Aboriginal population was investigated. Albendazole at a dose rate of 400 mg daily for 5 days was highly effective in reducing hookworm egg numbers and both Giardia antigen and cysts. The 36.6% prevalence of Giardia prior to treatment fell to 12% between days 6 and 9, 15% for days 10-17 and rose to 28% between days 18 and 30. Tolerability and clinical efficacy were excellent. The effect of albendazole on hookworm was longer lasting than that on Giardia, reducing percent infection from over 76-2% on days 6-9 and zero by day 18-30 despite conditions highly conducive to rapid re-infection. We conclude that albendazole is highly efficacious against both parasites when used as described but that long term community benefit may require additional education programmes to avoid re-infection with Giardia although treatment strategies would seem appropriate for hookworm.
Details
- Title
- Efficacy of albendazole against Giardia and hookworm in a remote Aboriginal community in the north of Western Australia
- Authors/Creators
- J.A. Reynoldson (Author/Creator)J.M. Behnke (Author/Creator)M. Gracey (Author/Creator)R.J. Horton (Author/Creator)R. Spargo (Author/Creator)R.M. Hopkins (Author/Creator)C.C. Constantine (Author/Creator)F. Gilbert (Author/Creator)C. Stead (Author/Creator)R.P. Hobbs (Author/Creator)R.C.A. Thompson (Author/Creator)
- Publication Details
- Acta Tropica, Vol.71(1), pp.27-44
- Publisher
- Elsevier BV
- Identifiers
- 991005545150607891
- Copyright
- © 1998 Elsevier Science B.V.
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.163 Parasitology - General
- 1.163.446 Schistosomiasis
- Web Of Science research areas
- Parasitology
- Tropical Medicine
- ESI research areas
- Clinical Medicine