Journal article
Efficacy of expired foot-and-mouth disease O type vaccines in cattle and buffalo in Lao People's Democratic Republic
Japan Agricultural Research Quarterly, Vol.50(2), pp.163-168
2016
Abstract
Lao People's Democratic Republic (Lao PDR) submitted a request to Japan for 200,000 doses of expired foot-and-mouth disease (FMD) O type vaccines that were in storage for emergency use. Approximately 100,000 animals, consisting of both cattle and Asian water buffalo (Bubalus bubalus bubalis), received the same vaccine twice within one month in Xieng Khouang province in the northeast area of Lao PDR. Concurrently, the efficacy of three-month expired FMD O type vaccine (6PD50 O Manisa) was assessed in serum samples of 90 cattle and 31 buffalo from the field using a Liquid Phase Blocking-ELISA (LPBE) assay. Of these samples, 75 cattle (83.3%) and 24 buffalo (77.4%) were seropositive against the FMD virus (FMDV) O type before vaccination. Testing for non-structural protein (NSP) using the PrioCHECK FMD NS kit showed that many of the animals with high titers in the screening test before vaccination were FMDV-infected animals. Fifteen cattle and seven buffalo with titers 1:32 or under before vaccination exhibited high titers of antibody (1:45-1:1448) one month after the first vaccination and further increased titers (1:362-1:5792) one month after the second vaccination. Nearly all of the cattle (97.6%) had high titers to control FMD 14 months after the second vaccination. To date, no outbreak of FMD has been reported at the study site. Three-month expired FMD O type vaccines induced appropriate immune responses against FMD in both cattle and buffalo.
Details
- Title
- Efficacy of expired foot-and-mouth disease O type vaccines in cattle and buffalo in Lao People's Democratic Republic
- Authors/Creators
- K. Sakamoto (Author/Creator)K. Morioka (Author/Creator)K. Fukai (Author/Creator)T. Yamamoto (Author/Creator)K. Tsutsui (Author/Creator)N. Muroga (Author/Creator)N. Ojima (Author/Creator)J. Mago (Author/Creator)Y. Katagiri (Author/Creator)S. Aviso (Author/Creator)M. Phouaravanh (Author/Creator)V. Soukvilay (Author/Creator)C. Keokhamphet (Author/Creator)C. Buranathai (Author/Creator)S. Khounsy (Author/Creator)M. Yamanda (Author/Creator)
- Publication Details
- Japan Agricultural Research Quarterly, Vol.50(2), pp.163-168
- Publisher
- Japan International Research Center for Agricultural Sciences
- Number of pages
- 6
- Identifiers
- 991005544689007891
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.104 Virology - General
- 1.104.901 Enterovirus Research
- Web Of Science research areas
- Agriculture, Multidisciplinary
- ESI research areas
- Agricultural Sciences